{"id":"W4410488951","doi":"10.1016/j.bneo.2025.100118","title":"Replication of a GWAS signal near HLA-DQA2 with AML using a disease-only cohort and external population-based controls","year":2025,"lang":"en","type":"article","venue":"Blood Neoplasia","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Centre Hospitalier Universitaire Sainte-Justine; Hôpital Maisonneuve-Rosemont; Université de Montréal; Montreal Heart Institute","funders":"Fondation Charles-Bruneau; Fondation Institut de Cardiologie de Montréal; Centre hospitalier universitaire Sainte-Justine; Canada Research Chairs; Fonds de Recherche du Québec - Santé; Cole Foundation; Ministère de l'Économie, de l’Innovation et des Exportations du Québec; Génome Québec; Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; Genome Canada","keywords":"Replication (statistics); Human leukocyte antigen; Cohort; Genome-wide association study; Population; Disease; Medicine; Biology; Immunology; Genetics; Virology; Internal medicine; Environmental health; Gene; Single-nucleotide polymorphism; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009406337,0.001074173,0.0007870065,0.0008888537,0.001533089,0.001252591,0.0009964567,0.0008579919,0.002638778],"category_scores_gemma":[0.01165657,0.0004322275,0.001804411,0.001254819,0.0007693911,0.0003232765,0.001138506,0.0009848741,0.0004428698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004344644,"about_ca_system_score_gemma":0.0005465825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01061579,"about_ca_topic_score_gemma":0.00908466,"domain_scores_codex":[0.9929544,0.002902531,0.0004792059,0.002551475,0.0007721016,0.0003403293],"domain_scores_gemma":[0.993002,0.001646091,0.0007198833,0.003561062,0.0007122018,0.0003587924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00323216,0.000298431,0.9111717,0.0001352498,0.005103012,0.001923288,0.001261496,0.0008681513,0.06326629,0.0007278695,0.001838753,0.01017357],"study_design_scores_gemma":[0.0009210241,0.0008999066,0.9804622,0.0000363007,0.002313066,0.001693406,0.0003584225,0.001585572,0.006269262,0.0005069889,0.004913839,0.00003998553],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899548,0.0002824276,0.006439617,0.0001467286,0.00008140667,0.0001147589,0.002042646,0.00007597893,0.0008615767],"genre_scores_gemma":[0.9963738,0.00004593512,0.001575676,0.0000950837,0.0000253509,0.00009139228,0.001430405,0.00003977902,0.0003224564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01061579,"threshold_uncertainty_score":0.0497461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006584351798126484,"score_gpt":0.2248328755712365,"score_spread":0.21824852377311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}