{"id":"W4410497778","doi":"10.1111/febs.70136","title":"Increased chromatin accessibility underpins senescence","year":2025,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Institute of Cancer Research","keywords":"Chromatin; Senescence; Telomere; Biology; Cell biology; Chromatin remodeling; Context (archaeology); Histone; Epigenome; Cellular senescence; Epigenetics; Genetics; DNA methylation; Phenotype; Gene expression; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009601451,0.0007086595,0.002928727,0.0006200871,0.000364924,0.0002134439,0.0006939794,0.0005530156,0.0008901086],"category_scores_gemma":[0.001163076,0.0005154376,0.001104208,0.001026666,0.0001721376,0.0002134918,0.0001787021,0.001971907,0.0001805554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006474368,"about_ca_system_score_gemma":0.004907194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004847878,"about_ca_topic_score_gemma":0.00001569438,"domain_scores_codex":[0.9958349,0.0005364654,0.001524692,0.0006746116,0.0007606604,0.0006686361],"domain_scores_gemma":[0.9967606,0.000487272,0.0008797222,0.0009381864,0.000289948,0.000644291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004134793,0.0002542162,0.0004315925,0.0350638,0.0002804599,0.0006953885,0.00004337078,7.386467e-8,0.00001342675,0.00002710279,0.005478083,0.9576711],"study_design_scores_gemma":[0.0008997242,0.000145247,0.002249489,0.08669288,0.002005458,0.004823957,0.00004381872,0.000008837321,0.00001650607,0.00012399,0.9024011,0.0005889547],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001553962,0.9943019,0.0004819317,0.0001493859,0.001018252,0.0008177929,0.0000591952,0.0001232829,0.002892825],"genre_scores_gemma":[0.0004060399,0.9946232,0.001053992,0.0003495753,0.001182986,0.00002610098,0.00009951492,0.00005990293,0.002198688],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9570822,"threshold_uncertainty_score":0.9997297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05698220417639017,"score_gpt":0.3838276429803917,"score_spread":0.3268454388040015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}