{"id":"W4410500205","doi":"10.1002/alz.70263","title":"Characterizing bidirectional transitions in mild cognitive impairment and post‐reversion based on longitudinal neuroimaging and cognitive assessments","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; Servier; National Institutes of Health; Natural Science Foundation of Shanxi Province; National Natural Science Foundation of China; Eisai; F. Hoffmann-La Roche; Grifols; Takeda Pharmaceutical Company; IXICO; Northern California Institute for Research and Education; Lundbeck Canada; University of Southern California; Pfizer; BioClinica; Biogen; Eli Lilly and Company; Euroimmun Medizinische Labordiagnostika; Bristol-Myers Squibb; Alzheimer's Association; Fujirebio US; Novartis Pharmaceuticals Corporation; Alzheimer's Drug Discovery Foundation; Meso Scale Diagnostics; Janssen Alzheimer Immunotherapy Research And Development; AbbVie","keywords":"Reversion; Cognition; Neuropsychology; Mean reversion; Cohort; Psychology; Neuroimaging; Cognitive decline; Longitudinal study; Cognitive neuropsychology; Audiology; Medicine; Neuroscience; Internal medicine; Dementia; Statistics; Pathology; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002677496,0.0003331603,0.0003171131,0.001554444,0.0002750325,0.0007171835,0.000375308,0.0004445683,0.0007739375],"category_scores_gemma":[0.005512577,0.0001692766,0.000575124,0.0006609222,0.0002636751,0.0004789981,0.0006690829,0.0004234922,0.0001352463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003596571,"about_ca_system_score_gemma":0.0006010704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007501725,"about_ca_topic_score_gemma":0.01268291,"domain_scores_codex":[0.9996111,0.0001435684,0.00003997698,0.0001082033,0.00004499313,0.00005216159],"domain_scores_gemma":[0.9979584,0.0006319236,0.0008556821,0.0002300264,0.000172983,0.0001509363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00027577,0.00006527457,0.9840118,0.00002476606,0.0001617191,0.00008212681,0.0001353312,0.002219581,0.000746774,0.000172414,0.0001606818,0.0119437],"study_design_scores_gemma":[0.00001177644,0.0002543352,0.965436,0.0000253855,0.0001093292,0.0002814998,0.0001455393,0.03122355,0.0007583638,0.001387064,0.0003468663,0.00002013595],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952382,0.000203014,0.003483329,0.00005270799,0.000003255001,0.00001853769,0.0006801155,0.00003506267,0.0002858643],"genre_scores_gemma":[0.9981568,0.00006100609,0.001153192,0.00001144878,0.000004015209,0.00001837817,0.0004978658,0.000002674909,0.00009445402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007501725,"threshold_uncertainty_score":0.01491612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02885603403665001,"score_gpt":0.3405618698930359,"score_spread":0.3117058358563859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}