{"id":"W4410502814","doi":"10.1093/sleep/zsaf090.0828","title":"0828 Impact of AXS-12 on Symptom Severity and Functional Impairment in Narcolepsy: Results from the Phase 3 SYMPHONY Trial","year":2025,"lang":"en","type":"article","venue":"SLEEP","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Narcolepsy; Symphony; Medicine; Functional impairment; Audiology; Internal medicine; Physical medicine and rehabilitation; Psychiatry; Modafinil; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001155057,0.0007512179,0.001643239,0.000170267,0.0002858906,0.0007201422,0.0004655265,0.001088689,0.006555375],"category_scores_gemma":[0.000789548,0.0001832544,0.001848728,0.0002051594,0.0004973414,0.0005205478,0.0002780217,0.001482795,0.0005905447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000345218,"about_ca_system_score_gemma":0.000485857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007074067,"about_ca_topic_score_gemma":0.001886811,"domain_scores_codex":[0.9996765,0.0001845272,0.00002321299,0.00003697966,0.00003171439,0.00004705001],"domain_scores_gemma":[0.9995307,0.0001169235,0.0001379953,0.00003666569,0.0000442644,0.0001336154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9485788,0.002160916,0.003158888,0.001930811,0.002378001,0.00008146575,0.00007168802,0.0004873924,0.003394576,0.0001758095,0.003992714,0.033589],"study_design_scores_gemma":[0.8804541,0.08718454,0.02667887,0.0002145748,0.001854044,0.0001403609,0.00007548221,0.0007420528,0.0005288097,0.0002980575,0.001795157,0.00003393578],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862273,0.00801825,0.0001635833,0.0006406603,0.0001688592,0.000578069,0.001574548,0.00007309849,0.002555676],"genre_scores_gemma":[0.9912046,0.002637389,0.0003477352,0.0007488531,0.0001951537,0.001059508,0.001826759,0.00001634955,0.001963648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006555375,"threshold_uncertainty_score":0.02192992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04308968309098237,"score_gpt":0.3473248473574017,"score_spread":0.3042351642664193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}