{"id":"W4410503366","doi":"10.1093/sleep/zsaf090.0861","title":"0861 A Phase 2a, Double-blind, Placebo-controlled Study of ORX750 in Patients with Narcolepsy (type 1 and 2) and Idiopathic Hypersomnia: Study Design","year":2025,"lang":"en","type":"article","venue":"SLEEP","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Narcolepsy; Placebo; Medicine; Double blind; Double blind study; Pediatrics; Physical therapy; Anesthesia; Psychiatry; Modafinil; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004358848,0.002867374,0.004406087,0.0007320079,0.0007686533,0.001201588,0.001527787,0.002701657,0.009198665],"category_scores_gemma":[0.001747139,0.001206926,0.002303977,0.0005885359,0.001591208,0.001301441,0.0005377964,0.002534373,0.001898164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008037718,"about_ca_system_score_gemma":0.003243499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000904283,"about_ca_topic_score_gemma":0.002933882,"domain_scores_codex":[0.9983829,0.0007922549,0.0001181638,0.0002970314,0.0001417208,0.0002679011],"domain_scores_gemma":[0.9988981,0.0002043479,0.0001870593,0.0001179772,0.0001319737,0.0004605231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9303063,0.03753797,0.0008610545,0.001251488,0.001031336,0.00007466185,0.00007073387,0.0004214625,0.01101226,0.0001818713,0.001292656,0.01595821],"study_design_scores_gemma":[0.8414921,0.1557173,0.001178373,0.00001819167,0.0002441639,0.00001861267,0.00001023038,0.0001452105,0.0003441528,0.00006345582,0.0007532436,0.00001482689],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9064287,0.004838187,0.001916545,0.0008607905,0.0009808239,0.07645965,0.003873476,0.0002720799,0.0043697],"genre_scores_gemma":[0.8910225,0.003498058,0.007518328,0.003082617,0.0009920674,0.08267663,0.002468882,0.00004948916,0.008691538],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.009198665,"threshold_uncertainty_score":0.03077263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05071431972628338,"score_gpt":0.3307198876096675,"score_spread":0.2800055678833841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}