{"id":"W4410503366","doi":"10.1093/sleep/zsaf090.0861","title":"0861 A Phase 2a, Double-blind, Placebo-controlled Study of ORX750 in Patients with Narcolepsy (type 1 and 2) and Idiopathic Hypersomnia: Study Design","year":2025,"lang":"en","type":"article","venue":"SLEEP","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Narcolepsy; Placebo; Medicine; Double blind; Double blind study; Pediatrics; Physical therapy; Anesthesia; Psychiatry; Modafinil; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000792342,0.0002245327,0.0005584823,0.0005013869,0.0001823328,0.00008090227,0.000240275,0.00006524706,0.00001183488],"category_scores_gemma":[0.0004329378,0.0001686374,0.00001949067,0.001219449,0.0001469663,0.0001735282,0.0001732679,0.0002981625,0.000003266558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003504076,"about_ca_system_score_gemma":0.00008798006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001211517,"about_ca_topic_score_gemma":0.0001198605,"domain_scores_codex":[0.9973845,0.0006514359,0.0003869923,0.0006360186,0.0005873049,0.0003537457],"domain_scores_gemma":[0.9989688,0.0003171238,0.0001016425,0.0003537796,0.0001563261,0.0001022602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3792382,0.02048372,0.581011,0.00007588428,0.0001545994,0.0001716565,0.006770323,0.0001756789,0.002282189,0.00007714393,0.00001062114,0.009549014],"study_design_scores_gemma":[0.9066817,0.01931879,0.05976963,0.0001195618,0.000257688,0.000003763753,0.006426506,0.002338341,0.004590139,0.000067741,0.000008402951,0.0004177752],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931573,0.000108696,0.00007672171,0.00003217943,0.00009924162,0.006292049,0.000003087818,0.00002499964,0.000205723],"genre_scores_gemma":[0.9994229,0.000005708663,0.00001432267,0.0000404858,0.0000102913,0.000407932,5.567189e-7,0.00001798782,0.00007983095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5274435,"threshold_uncertainty_score":0.6876836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05071431972628338,"score_gpt":0.3307198876096675,"score_spread":0.2800055678833841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}