{"id":"W4410503469","doi":"10.1007/s00281-025-01052-x","title":"Chimerism and immunological tolerance in solid organ transplantation","year":2025,"lang":"en","type":"review","venue":"Seminars in Immunopathology","topic":"Organ and Tissue Transplantation Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Universitätsklinikum Hamburg-Eppendorf; Werner Otto Stiftung; Jung-Stiftung für Wissenschaft und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Microchimerism; Immunology; Immune tolerance; Transplacental; Transplantation; Organ transplantation; Solid organ; Immune system; Medicine; Immunosuppression; Pregnancy; Chimera (genetics); Fetus; Biology; Placenta; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000507527,0.0003547779,0.001821544,0.0008915464,0.0000472121,0.00001434447,0.0001876297,0.0006730169,0.0001309851],"category_scores_gemma":[0.0001001787,0.0003116807,0.0001117968,0.0007549563,0.0002520209,0.00004709972,0.00004825068,0.001224445,0.00005276559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001056124,"about_ca_system_score_gemma":0.0003041482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000021211,"about_ca_topic_score_gemma":0.0000186236,"domain_scores_codex":[0.9976208,0.0004214034,0.0007874815,0.0005430497,0.0001473736,0.0004799227],"domain_scores_gemma":[0.9991274,0.0003614604,0.0001105515,0.000320318,0.00003020081,0.00005001165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002421054,0.0001945185,0.0009031945,0.02627161,0.00003505985,0.00493876,0.0008532468,3.523737e-7,0.0003165348,0.0000901167,0.00001270087,0.9661418],"study_design_scores_gemma":[0.01650233,0.003080375,0.09219874,0.4405268,0.002661129,0.03969159,0.0008599618,0.00002316474,0.0007759597,0.0004371667,0.4004722,0.002770579],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.011193,0.9865364,0.00001019249,0.00009765616,0.0002153258,0.00100751,0.00003593239,0.00003670692,0.0008672484],"genre_scores_gemma":[0.001617881,0.9964591,0.0002587003,0.00005359572,0.00002828641,0.0001451596,0.0003196439,0.00003171724,0.001085923],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9633712,"threshold_uncertainty_score":0.9999335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02250241879128029,"score_gpt":0.372409247546131,"score_spread":0.3499068287548507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}