{"id":"W4410504006","doi":"10.1101/2025.05.16.654244","title":"Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Massachusetts Amherst; Canadian Institute for Advanced Research; Richard and Susan Smith Family Foundation","keywords":"Crawling; Myosin; Contractility; Actin; Lineage (genetic); Cell biology; Biophysics; Chemistry; Biology; Anatomy; Biochemistry; Gene; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001318955,0.000122986,0.0001211888,0.0004495106,0.000240962,0.0002944008,0.0001042176,0.0002308245,0.0006824186],"category_scores_gemma":[0.0001362611,0.00008751977,0.0001225405,0.0001665103,0.0002457996,0.0002225364,0.0004546361,0.0002370306,0.0002172066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002036964,"about_ca_system_score_gemma":0.0001165291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005724274,"about_ca_topic_score_gemma":0.001080639,"domain_scores_codex":[0.9999316,0.000007902707,0.000004999461,0.00002382563,0.00001514706,0.00001659061],"domain_scores_gemma":[0.9998955,0.00001718584,0.00003395882,0.0000152251,0.00001193842,0.00002618122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003683907,0.000005678585,0.011413,0.00002973012,0.000005438185,0.0001239263,0.00006020133,0.00006979994,0.9855687,0.0007346176,0.00005997578,0.001892098],"study_design_scores_gemma":[0.00002781046,0.0001682387,0.6395574,0.00005013875,0.0000368284,0.002013402,0.0007206543,0.00456195,0.3371343,0.00251812,0.01319101,0.00002016125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963966,0.0003748566,0.001282446,0.00004162401,0.00000676043,0.000003747987,0.00008721902,0.0000148632,0.001791956],"genre_scores_gemma":[0.9977087,0.0001640417,0.001022415,0.00002720265,0.000007191081,0.000004342395,0.0001800249,0.000006286173,0.000879893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006824186,"threshold_uncertainty_score":0.002282917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628506646044372,"score_gpt":0.2432769108691147,"score_spread":0.226991844408671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}