{"id":"W4410504118","doi":"10.1093/sleep/zsaf090.0843","title":"0843 ENCORE: Topline Results of a Phase 3 Open-Label Extension and Randomized-Withdrawal Trial of AXS-12 in Narcolepsy","year":2025,"lang":"en","type":"article","venue":"SLEEP","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Narcolepsy; Open label; Randomized controlled trial; Medicine; Psychiatry; Internal medicine; Modafinil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001915339,0.0008377235,0.001574989,0.0002504899,0.0003402901,0.0007876637,0.0005203588,0.001078333,0.01327135],"category_scores_gemma":[0.001468634,0.0002559618,0.001209075,0.000170843,0.0005015312,0.0008026157,0.0003626665,0.001780343,0.00150456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003878912,"about_ca_system_score_gemma":0.0007026122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005026705,"about_ca_topic_score_gemma":0.002411439,"domain_scores_codex":[0.9993292,0.0003804471,0.00003778601,0.00007850432,0.00008019327,0.0000939595],"domain_scores_gemma":[0.9990466,0.000222198,0.0001853319,0.00009076075,0.0001369942,0.0003181543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9007559,0.009048864,0.001475963,0.001111174,0.001358867,0.0001069839,0.0001078313,0.0003575085,0.01330366,0.0003238706,0.008235184,0.0638142],"study_design_scores_gemma":[0.8386029,0.1414926,0.01045393,0.0001110078,0.0007149299,0.0001203722,0.00005227094,0.0005353046,0.001495474,0.0002150995,0.006169662,0.00003643473],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780552,0.003998052,0.000844048,0.001177882,0.0004159678,0.002979871,0.004985757,0.0002899263,0.007253262],"genre_scores_gemma":[0.9708214,0.002351653,0.002767195,0.002279505,0.0004973803,0.004477168,0.005336687,0.00008576018,0.01138314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01327135,"threshold_uncertainty_score":0.04439712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06085023728172368,"score_gpt":0.388469124685413,"score_spread":0.3276188874036893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}