{"id":"W4410512934","doi":"10.3899/jrheum.2025-0390.pv251","title":"BE-EARLY: A PHASE 4, PROSPECTIVE, OPEN-LABEL STUDY TO EVALUATE THE IMPACT OF BELIMUMAB ON EARLY (≤ 2 YEARS) SYSTEMIC LUPUS ERYTHMETOSUS IN ADULTS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Belimumab; Open label; Systemic lupus erythematosus; Prospective cohort study; Open label study; Internal medicine; Immunology; Antibody; Clinical trial; Disease; Adverse effect; B-cell activating factor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002701975,0.001873154,0.002124705,0.0003858244,0.0005616832,0.001028272,0.0009200817,0.001886396,0.005347743],"category_scores_gemma":[0.001479762,0.0005396972,0.001310027,0.0003132985,0.0009597026,0.001275893,0.0006186435,0.003295602,0.001170527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006259406,"about_ca_system_score_gemma":0.001199599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004596914,"about_ca_topic_score_gemma":0.001316022,"domain_scores_codex":[0.9992772,0.0003810219,0.00003187278,0.0001074922,0.00007536381,0.000126957],"domain_scores_gemma":[0.9990517,0.0001627784,0.0002316482,0.00004906334,0.00007482457,0.0004299232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8281789,0.09087294,0.003855172,0.001896562,0.001636792,0.0002082402,0.0002354277,0.0008838638,0.01515002,0.0004034028,0.004448613,0.05223009],"study_design_scores_gemma":[0.5456238,0.4409361,0.007473053,0.0001062893,0.0005569694,0.0001484989,0.00007300528,0.0004522575,0.0009252716,0.0003403696,0.003328396,0.00003599268],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972038,0.009121798,0.001563633,0.001618468,0.0005344414,0.00909255,0.002575817,0.0002088974,0.00324646],"genre_scores_gemma":[0.96631,0.004494697,0.005263598,0.003906431,0.0006958015,0.01254796,0.0024662,0.0000429657,0.00427232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005347743,"threshold_uncertainty_score":0.01788992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03639747077639675,"score_gpt":0.3995559378036078,"score_spread":0.3631584670272111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}