{"id":"W4410512936","doi":"10.3899/jrheum.2025-0390.pv265","title":"SUPERDIMERIC ANTIBODY-LIKE MOLECULE WITH DUAL FC DOMAINS PROVIDES POTENT B CELL DEPLETION WITH MINIMAL CYTOKINE INDUCTION VIA TARGETING OF CD19, CD20 AND FC GAMMA RECEPTORS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CD19; Medicine; Receptor; CD20; Antibody; B cell; Cytokine; Immunology; Cell biology; Cancer research; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000647178,0.0001556933,0.0003916161,0.00008629957,0.0001119079,0.00001196089,0.0001250743,0.0001329734,0.00007741787],"category_scores_gemma":[0.000127813,0.00008073654,0.00005166141,0.0001652282,0.0002399118,0.00008099533,0.00004281067,0.0002428238,0.000001533847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003786088,"about_ca_system_score_gemma":0.00008878969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000925604,"about_ca_topic_score_gemma":0.0000205264,"domain_scores_codex":[0.9987408,0.0002029571,0.0005048026,0.0001460356,0.0002214592,0.0001839803],"domain_scores_gemma":[0.9987361,0.0002623677,0.0006332869,0.0001179782,0.000207336,0.00004295729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002602449,0.0001506142,0.1430578,0.0001578971,0.0001640442,0.000005479808,0.0003326826,0.0001222072,0.8506781,0.00002119052,0.0002108077,0.002496697],"study_design_scores_gemma":[0.005423366,0.004755109,0.04344701,0.001273655,0.0009507575,0.006325954,0.007706551,0.001739448,0.9259493,0.0003402788,0.001465885,0.0006226217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966748,0.0004883056,0.001815163,0.0006681941,0.00008146102,0.00008427939,0.000003038068,0.00001114074,0.0001736092],"genre_scores_gemma":[0.9980408,0.0004925909,0.001364573,0.00003076287,0.00001534208,0.000002823894,0.00001297134,0.00001016593,0.00002996953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09961081,"threshold_uncertainty_score":0.329234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008043180543888123,"score_gpt":0.2309243452511405,"score_spread":0.2228811647072524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}