{"id":"W4410512936","doi":"10.3899/jrheum.2025-0390.pv265","title":"SUPERDIMERIC ANTIBODY-LIKE MOLECULE WITH DUAL FC DOMAINS PROVIDES POTENT B CELL DEPLETION WITH MINIMAL CYTOKINE INDUCTION VIA TARGETING OF CD19, CD20 AND FC GAMMA RECEPTORS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CD19; Medicine; Receptor; CD20; Antibody; B cell; Cytokine; Immunology; Cell biology; Cancer research; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008036924,0.0002540224,0.0001168598,0.0001445449,0.00006366634,0.0001679129,0.0001709487,0.0002765523,0.001885476],"category_scores_gemma":[0.00003619591,0.0000796876,0.0001499565,0.000111957,0.00008970371,0.0001166868,0.0001442969,0.0002904575,0.0006463745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001842118,"about_ca_system_score_gemma":0.0000806527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003079259,"about_ca_topic_score_gemma":0.0003232229,"domain_scores_codex":[0.9999481,0.000008789322,0.000003241837,0.00001070238,0.00001499934,0.00001409111],"domain_scores_gemma":[0.9999756,0.000002080809,0.000007067119,0.000002200209,0.000002387571,0.00001074992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009054426,0.00003232315,0.00009380597,0.00002157198,0.000005019408,0.00003339251,0.000005057049,0.0001183776,0.9960706,0.0001016611,0.0001751743,0.003252402],"study_design_scores_gemma":[0.00005752703,0.0006634832,0.002284581,0.000004406048,0.00002787931,0.0003985026,0.000006762622,0.001468914,0.9839113,0.00003192084,0.01113909,0.000005640228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982421,0.001878362,0.008213711,0.0001438845,0.00003997339,0.00009103044,0.0004428774,0.0003595884,0.00640965],"genre_scores_gemma":[0.9876853,0.0007395526,0.005516734,0.00008595186,0.00001286036,0.00004211981,0.0006805149,0.00002702396,0.005210086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001885476,"threshold_uncertainty_score":0.006307542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008043180543888123,"score_gpt":0.2309243452511405,"score_spread":0.2228811647072524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}