{"id":"W4410512947","doi":"10.3899/jrheum.2025-0390.o026","title":"MULTI-OMIC INTEGRATION REVEALS THREE MOLECULAR SUBTYPES WITH DISTINCT IMMUNOLOGICAL PHENOTYPES IN A COHORT OF 722 SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Phenotype; Cohort; Systemic disease; Immunology; Immunopathology; Pathology; Gene; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006606659,0.0003358547,0.0006335449,0.00114477,0.0005832763,0.000861693,0.000280749,0.0003878386,0.001427071],"category_scores_gemma":[0.001498905,0.0002006511,0.0005750231,0.001400545,0.0002241191,0.0002811221,0.0006418488,0.0004874211,0.0002879451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003262634,"about_ca_system_score_gemma":0.000266061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00274125,"about_ca_topic_score_gemma":0.00334641,"domain_scores_codex":[0.9995055,0.0001022616,0.00004448359,0.0001923753,0.00008157024,0.00007375698],"domain_scores_gemma":[0.9993932,0.0001332954,0.0002075541,0.00008609754,0.00007253805,0.0001073242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009603443,0.00006377116,0.9861355,0.00002237716,0.0001907892,0.0003235647,0.0001774255,0.0002733104,0.004965243,0.00005208689,0.0004936085,0.006342043],"study_design_scores_gemma":[0.00003373093,0.0001226616,0.9965851,0.000006046556,0.00008872039,0.0006237823,0.0002533473,0.001389396,0.0003829956,0.0001255324,0.0003779765,0.00001043908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988469,0.00009015914,0.0002079327,0.00003447727,0.000002047763,0.000009013468,0.0006903163,0.000007085461,0.0001120076],"genre_scores_gemma":[0.9981208,0.00003738586,0.0002554721,0.00002371497,0.000006384752,0.00001492252,0.001429496,0.000005646434,0.0001060941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00274125,"threshold_uncertainty_score":0.005450666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01243567354357267,"score_gpt":0.2729845746360399,"score_spread":0.2605489010924672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}