{"id":"W4410512960","doi":"10.3899/jrheum.2025-0390.pv116","title":"DISTINCT CELL-BOUND COMPLEMENT ACTIVATION PRODUCTS ASSOCIATE WITH DISEASE ACTIVITY AND IMMUNE TRANSCRIPTIONAL SIGNATURES IN SLE","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Autoimmune Bullous Skin Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Immune system; Complement (music); Complement system; Immunology; Autoimmune disease; Disease; Immunopathology; Cell; Antibody; Gene; Genetics; Pathology; Biology; Phenotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002192246,0.0001977199,0.0003054701,0.0004559368,0.0002558954,0.0006355667,0.00009316103,0.0003304339,0.005143303],"category_scores_gemma":[0.0002673864,0.0001455952,0.0002968999,0.0004660644,0.0001918514,0.0001533482,0.000311976,0.0004822904,0.0008277703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002081419,"about_ca_system_score_gemma":0.0001651881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004541856,"about_ca_topic_score_gemma":0.0006699261,"domain_scores_codex":[0.999804,0.00002156467,0.00001555369,0.00007460555,0.00003475279,0.00004954138],"domain_scores_gemma":[0.9998199,0.000041213,0.00005830462,0.00001376416,0.0000265692,0.00004029855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00208323,0.0001143261,0.1962446,0.0003378631,0.0001113822,0.0002469817,0.0004660235,0.0005390528,0.772821,0.000256241,0.001762229,0.0250171],"study_design_scores_gemma":[0.00003259418,0.0004884836,0.9613918,0.00006208087,0.0001025019,0.000813806,0.0005645557,0.00127436,0.03066848,0.0004019962,0.004170386,0.0000289487],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925728,0.001434479,0.0009437621,0.000100154,0.0000244733,0.00001639879,0.003767497,0.00003785182,0.001102496],"genre_scores_gemma":[0.9924483,0.0005507375,0.001123107,0.0001776727,0.00003488112,0.00005234195,0.003616623,0.00002495975,0.001971335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005143303,"threshold_uncertainty_score":0.01720607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009359236129315617,"score_gpt":0.253714276734868,"score_spread":0.2443550406055524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}