{"id":"W4410512962","doi":"10.3899/jrheum.2025-0390.o028","title":"TRANSCRIPTOME ANALYSIS OF QUIESCENT SLE CASES UNCOVERS DYSREGULATED PATHWAYS ASSOCIATED WITH DISEASE FLARES","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Skin Protection and Aging","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Transcriptome; Medicine; Disease; Computational biology; Immunology; Bioinformatics; Gene; Genetics; Internal medicine; Gene expression; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003990381,0.00009740403,0.0005612033,0.0004960658,0.00007013197,0.000005197327,0.0001027525,0.00004859514,0.00008591783],"category_scores_gemma":[0.0004281237,0.00005490057,0.000192589,0.00097068,0.0001385194,0.00004045138,0.0000117011,0.0001993437,5.379337e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006923702,"about_ca_system_score_gemma":0.0002120357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001464606,"about_ca_topic_score_gemma":0.0001200751,"domain_scores_codex":[0.9989469,0.0001970451,0.0004334333,0.00007040764,0.0002123359,0.0001399001],"domain_scores_gemma":[0.9988303,0.0003108895,0.0003768622,0.0001580847,0.0002438193,0.00008001542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004958307,0.0004098338,0.9660104,0.0001186839,0.01147969,0.0002063961,0.001655574,0.002884152,0.009607214,0.0006502644,0.001367835,0.0006516667],"study_design_scores_gemma":[0.01740242,0.002072955,0.8856195,0.005265551,0.04331787,0.003979132,0.01018866,0.007075852,0.02240485,0.0008832217,0.001282926,0.000507086],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961613,0.0008358204,0.001023318,0.001592702,0.0001887425,0.0001051579,0.000008784897,0.00001534933,0.00006879697],"genre_scores_gemma":[0.9994587,0.0002149927,0.00001785478,0.0001850091,0.000001872439,0.000001079442,0.000005035996,0.000006187954,0.0001092933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08039091,"threshold_uncertainty_score":0.223878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423715722710158,"score_gpt":0.2560401407803439,"score_spread":0.2418029835532423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}