{"id":"W4410512981","doi":"10.3899/jrheum.2025-0390.pv259","title":"A SELECTIVE SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 INHIBITOR ALLEVIATES THE MURINE LUPUS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; STAT protein; Transducer; Systemic lupus erythematosus; Activator (genetics); Transcription (linguistics); Lupus erythematosus; Immunology; Cancer research; Pharmacology; Cell biology; Internal medicine; Signal transduction; STAT3; Receptor; Acoustics; Antibody; Disease; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004892042,0.00008995536,0.0002593541,0.00008878855,0.0001467007,0.00001339162,0.0002218101,0.0000520744,0.00007413399],"category_scores_gemma":[0.0001266205,0.00004574312,0.00007909404,0.0001888376,0.0002527863,0.00009916124,0.00001906994,0.0002980963,0.000001260862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001512812,"about_ca_system_score_gemma":0.00005614647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003482825,"about_ca_topic_score_gemma":0.0000102037,"domain_scores_codex":[0.9988707,0.0004096481,0.0003651529,0.00008281796,0.0001380253,0.0001336832],"domain_scores_gemma":[0.998899,0.000677973,0.0002495953,0.00007893034,0.00006710265,0.00002741852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006608948,0.00006160488,0.003581927,0.00004200019,0.00005109897,0.000001096033,0.003464289,0.00004899672,0.9872355,0.001846132,0.001002681,0.002003769],"study_design_scores_gemma":[0.0016931,0.0005329351,0.001292119,0.0002823735,0.0001184929,0.002818128,0.001316676,0.0004860054,0.9826645,0.004947035,0.003725781,0.0001229134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947525,0.0004652639,0.0006138252,0.003516377,0.0003999051,0.0001070263,0.00000169547,0.000005720453,0.0001376327],"genre_scores_gemma":[0.9989388,0.0007709585,0.00003044019,0.0001683989,0.000009977727,9.832066e-7,4.634224e-8,0.000007331142,0.00007309119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00457107,"threshold_uncertainty_score":0.186535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307519659233334,"score_gpt":0.2428782457069859,"score_spread":0.2298030491146526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}