{"id":"W4410512997","doi":"10.3899/jrheum.2025-0390.pv228","title":"A NOVEL MODELING APPROACH TO ELUCIDATE THE ROLE OF AUTOANTIBODIES IN COMPLEMENT ACTIVATION IN SLE","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Autoantibody; Complement (music); Complement system; Immunology; Computational biology; Antibody; Genetics; Phenotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006403201,0.0009391968,0.0008535848,0.0007219944,0.0005658883,0.0009432525,0.001258451,0.001588405,0.005391935],"category_scores_gemma":[0.001762774,0.0005136291,0.001402934,0.0005708419,0.0003156857,0.00058494,0.0008086949,0.0008480158,0.0004952056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008427476,"about_ca_system_score_gemma":0.001805085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02829581,"about_ca_topic_score_gemma":0.01720616,"domain_scores_codex":[0.9997995,0.00007821491,0.00001045463,0.00003383734,0.00002707046,0.00005092634],"domain_scores_gemma":[0.9992383,0.0004557351,0.00008257803,0.00003529291,0.0001332662,0.00005487532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00004013862,0.00005712617,0.002008981,0.00002337443,0.00003077649,0.00008723469,0.00002445747,0.9896402,0.0005712388,0.004336673,0.0005802196,0.002599511],"study_design_scores_gemma":[0.000005866905,0.000008507721,0.0001075778,0.000003167065,0.00000586625,0.000008207116,0.000006821077,0.9986994,0.00004519901,0.0008061112,0.000300702,0.000002520505],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3157813,0.001490791,0.6302605,0.002405744,0.0003318116,0.0003112011,0.003289175,0.0009994637,0.04513006],"genre_scores_gemma":[0.9094906,0.0008729747,0.07081544,0.0004379695,0.0001634513,0.0005871712,0.001512863,0.0001763801,0.01594305],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02829581,"threshold_uncertainty_score":0.05626225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02199468805315808,"score_gpt":0.2754393730653669,"score_spread":0.2534446850122088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}