{"id":"W4410512997","doi":"10.3899/jrheum.2025-0390.pv228","title":"A NOVEL MODELING APPROACH TO ELUCIDATE THE ROLE OF AUTOANTIBODIES IN COMPLEMENT ACTIVATION IN SLE","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Autoantibody; Complement (music); Complement system; Immunology; Computational biology; Antibody; Genetics; Phenotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001041983,0.00009573187,0.0003760913,0.0003090826,0.00006709169,0.000004258728,0.0004589171,0.00005091673,0.00002614888],"category_scores_gemma":[0.000141289,0.00005684509,0.00005420082,0.000227873,0.00007343019,0.00004739548,0.0001555908,0.0002169959,0.000004212255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000536633,"about_ca_system_score_gemma":0.0000914312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150591,"about_ca_topic_score_gemma":0.0003067559,"domain_scores_codex":[0.9985182,0.0003865107,0.000768476,0.00008436245,0.00004440698,0.0001981028],"domain_scores_gemma":[0.9990191,0.0003720196,0.0003095521,0.0002067549,0.00008506681,0.000007442536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002560825,0.001517707,0.3824074,0.0002373662,0.0008800897,5.650194e-7,0.01426512,0.08581672,0.4329202,0.07327747,0.002529328,0.003587205],"study_design_scores_gemma":[0.04311214,0.001883737,0.332386,0.0102452,0.0009543157,0.003540199,0.2240234,0.1111463,0.177379,0.06908573,0.0242929,0.001951132],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833493,0.001310876,0.01312845,0.00114368,0.0002170625,0.0003036729,0.000005699405,0.000004452606,0.0005368725],"genre_scores_gemma":[0.999648,0.00005369903,0.0001846135,0.00006677777,0.000001383785,0.00001031197,0.000004477274,0.000004357578,0.00002634431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2555413,"threshold_uncertainty_score":0.2318075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02199468805315808,"score_gpt":0.2754393730653669,"score_spread":0.2534446850122088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}