{"id":"W4410513006","doi":"10.3899/jrheum.2025-0390.pv113","title":"TRANSCRIPTOMIC ANALYSIS REVEALS A SYNERGY OF HYDROXYCHLOROQUINE AND GLUCOCORTICOIDS IN MODULATING B CELL-RELATED IMMUNE PROCESSES","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Hydroxychloroquine; Medicine; Immune system; Transcriptome; Immunopathology; Immunology; Computational biology; Internal medicine; Genetics; Gene expression; Gene; Coronavirus disease 2019 (COVID-19); Biology; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001758906,0.0001531235,0.0003093737,0.0003736287,0.0001876147,0.0004028835,0.0001057949,0.0002399505,0.001294425],"category_scores_gemma":[0.000178107,0.0000934249,0.0002886879,0.0004554683,0.0001847509,0.0001327638,0.0001470995,0.0002329667,0.0002580925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001873973,"about_ca_system_score_gemma":0.0001645412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005848734,"about_ca_topic_score_gemma":0.001000974,"domain_scores_codex":[0.9998041,0.00003116115,0.000009234984,0.00007539125,0.00003944784,0.00004076286],"domain_scores_gemma":[0.999843,0.00004234561,0.00005742906,0.00001321386,0.0000236388,0.00002039182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005172464,0.00003021298,0.02188651,0.000111094,0.00005504851,0.0001170223,0.00007132453,0.0001402538,0.9707643,0.00007167932,0.000174462,0.00606085],"study_design_scores_gemma":[0.00003476817,0.0005890838,0.8977087,0.00003910422,0.0001764519,0.0006131337,0.0004273635,0.002131986,0.09485407,0.0003131018,0.003093551,0.00001877437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919556,0.002902198,0.001450593,0.0001454171,0.00001963496,0.00001772812,0.002731017,0.00003417817,0.0007437051],"genre_scores_gemma":[0.9941691,0.0008360894,0.001865366,0.0001412021,0.00002819338,0.00003040603,0.002168826,0.00001197599,0.0007487235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294425,"threshold_uncertainty_score":0.004330337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003625518020641108,"score_gpt":0.215002714288431,"score_spread":0.2113771962677899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}