{"id":"W4410513030","doi":"10.3899/jrheum.2025-0390.pv110","title":"EPIGENETIC PROFILING OF CHILDHOOD-ONSET LUPUS REVEALS DISTINCT EPIGENETIC CLUSTERS AND SUGGESTS EPIGENETIC DRIVERS OF DISEASE ACTIVITY","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Birth, Development, and Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Epigenetics; Medicine; Epigenesis; Disease; DNA methylation; Systemic lupus erythematosus; Profiling (computer programming); Genetics; Bioinformatics; Gene; Biology; Gene expression; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001661672,0.0001514899,0.0002495714,0.000569919,0.0001523119,0.0003348929,0.000116129,0.0002093868,0.003691946],"category_scores_gemma":[0.000319445,0.00009489417,0.0002062653,0.0006015733,0.0001435155,0.0001073308,0.0002166058,0.0002262186,0.0003957579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002519697,"about_ca_system_score_gemma":0.0001197785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008177696,"about_ca_topic_score_gemma":0.001380226,"domain_scores_codex":[0.9998636,0.00002003136,0.000008695878,0.00005635373,0.00002532747,0.00002599105],"domain_scores_gemma":[0.9998099,0.00003872421,0.00008614954,0.00001491463,0.00002234426,0.0000279859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001779085,0.00009143393,0.5911002,0.0003357395,0.000206743,0.0008023398,0.0004446767,0.0004743935,0.3275067,0.0004717475,0.001847708,0.07493918],"study_design_scores_gemma":[0.000009256421,0.0001740194,0.9811764,0.00002239427,0.00007482113,0.001275074,0.0001221338,0.0003409482,0.01438338,0.0001985364,0.002215142,0.00000798325],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913625,0.002290438,0.001468373,0.0001229977,0.00001202326,0.00001429869,0.002897514,0.0000602793,0.001771494],"genre_scores_gemma":[0.9939402,0.001155634,0.001690953,0.00006855959,0.0000148931,0.00001734171,0.00183108,0.00002431215,0.001257052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003691946,"threshold_uncertainty_score":0.0123508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01156112247962199,"score_gpt":0.2794227029204684,"score_spread":0.2678615804408465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}