{"id":"W4410513084","doi":"10.3899/jrheum.2025-0390.o022","title":"ALTERATIONS IN INNATE IMMUNE POPULATIONS DURING SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASE DEVELOPMENT","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Hospital for Sick Children; Toronto Western Hospital; University of Toronto","funders":"","keywords":"Medicine; Immunology; Innate immune system; Autoimmune disease; Systemic disease; Immune system; Rheumatic disease; Disease; Immunopathology; Rheumatoid arthritis; Antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003849553,0.0001839766,0.0003833453,0.0002916263,0.0002140591,0.0005929094,0.0001341964,0.0002926275,0.00329788],"category_scores_gemma":[0.0002768095,0.0001427933,0.00036796,0.0002423095,0.000197311,0.000257014,0.0004063778,0.0004634804,0.001013541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372635,"about_ca_system_score_gemma":0.0002131831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002379708,"about_ca_topic_score_gemma":0.0004989012,"domain_scores_codex":[0.999687,0.00004762537,0.00002208833,0.00009252127,0.00008634439,0.00006449466],"domain_scores_gemma":[0.9997973,0.00004167814,0.00004941751,0.00001832671,0.00005390169,0.00003942637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001084412,0.00006716694,0.06254321,0.0004906109,0.00005882591,0.0001773536,0.000319454,0.0003288022,0.9046754,0.0002491757,0.001546963,0.02845867],"study_design_scores_gemma":[0.00006280166,0.0009995574,0.8378776,0.0001867306,0.0001413915,0.001119973,0.000948943,0.002244026,0.1401028,0.0007110617,0.01556394,0.00004127161],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840147,0.003571435,0.002742414,0.0002193955,0.0000744995,0.00005590077,0.005856401,0.0001176162,0.003347658],"genre_scores_gemma":[0.9831503,0.001890761,0.003731837,0.0004552769,0.00004592813,0.0001589113,0.00677111,0.00004695832,0.003748878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00329788,"threshold_uncertainty_score":0.01103246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116254563771554,"score_gpt":0.2378493583085568,"score_spread":0.2262239019314014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}