{"id":"W4410513089","doi":"10.3899/jrheum.2025-0390.o023","title":"NEUTROPHIL EXTRACELLULAR TRAPS ARE SUFFICIENT TO ACTIVATE THE ALTERNATIVE PATHWAY OF COMPLEMENT, WHICH IS CONSTITUITIVELY ACTIVE IN HUMAN SLE","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Neutrophil extracellular traps; Complement (music); Extracellular; Complement system; Alternative complement pathway; Immunology; Cell biology; Inflammation; Genetics; Antibody; Gene; Biology; Phenotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000198058,0.0002316948,0.0001518747,0.000152919,0.00009998722,0.0002115767,0.0001346235,0.0003337952,0.002938473],"category_scores_gemma":[0.0002590053,0.00008481492,0.000127537,0.0000879831,0.0001104707,0.0001176889,0.0001484364,0.0003575781,0.0004017768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001865046,"about_ca_system_score_gemma":0.0001932817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007244908,"about_ca_topic_score_gemma":0.00125241,"domain_scores_codex":[0.9998354,0.00003350632,0.00001496119,0.00002325044,0.00005214355,0.00004073977],"domain_scores_gemma":[0.9998938,0.00002562594,0.00002456831,0.00001232256,0.00001210071,0.0000315565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004301646,0.00005957996,0.0005397233,0.00006716642,0.000008968605,0.000193589,0.00001977499,0.00006100938,0.9952812,0.000185465,0.000208494,0.002944818],"study_design_scores_gemma":[0.0001573541,0.001599228,0.01895544,0.00002307682,0.00002573873,0.001952954,0.00006664718,0.00118768,0.9681687,0.000182954,0.007669628,0.00001063498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905173,0.003908554,0.001998777,0.0002129782,0.0000902759,0.00007737621,0.0006384643,0.00007850565,0.002477593],"genre_scores_gemma":[0.9967435,0.0003974642,0.0008517848,0.0000585477,0.0000217649,0.0000255252,0.000563381,0.000003335895,0.001334697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002938473,"threshold_uncertainty_score":0.009830177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01986423737831798,"score_gpt":0.2689926784633104,"score_spread":0.2491284410849924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}