{"id":"W4410513093","doi":"10.3899/jrheum.2025-0390.pv114","title":"EXTRACELLULAR VESICLES FROM LUPUS NEPHRITIS PATIENTS INDUCE CHANGES IN THE TRANSCRIPTIONAL PROFILE OF MONOCYTES THAT RESEMBLE SLAN+ MONOCYTES","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Monocyte; Medicine; Extracellular vesicles; Lupus nephritis; Immunology; Nephritis; Extracellular; Pathology; Cell biology; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009445695,0.0001142467,0.0002625428,0.000203218,0.0001580417,0.0002300957,0.00005954909,0.0002060534,0.00231551],"category_scores_gemma":[0.0001730075,0.0000890771,0.000203675,0.0001443053,0.0001190578,0.00007438047,0.0001731078,0.0002827659,0.0003352523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007817594,"about_ca_system_score_gemma":0.00006927142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000172329,"about_ca_topic_score_gemma":0.0002347807,"domain_scores_codex":[0.9998375,0.00002639596,0.00001848836,0.00004724447,0.00002713316,0.0000431323],"domain_scores_gemma":[0.9999025,0.00002310585,0.00002458946,0.00001096267,0.00001390321,0.00002496704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002310898,0.00008719479,0.01073103,0.00009712201,0.00001959494,0.0004199344,0.0001686787,0.00003611438,0.9821207,0.00003778469,0.0001440064,0.003826979],"study_design_scores_gemma":[0.0001800619,0.003961699,0.579141,0.00004893114,0.0001375486,0.004493376,0.001211482,0.0005823509,0.4047095,0.000239806,0.005264558,0.00002974088],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986116,0.0003932204,0.0002937698,0.00002894394,0.0000156988,0.00001005176,0.0003470888,0.000008776409,0.0002909568],"genre_scores_gemma":[0.9975953,0.0002274257,0.0004017432,0.00007490662,0.00001944708,0.00003629533,0.000686631,0.000006458066,0.0009517575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00231551,"threshold_uncertainty_score":0.00774622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520730808663704,"score_gpt":0.2481050845870583,"score_spread":0.2328977765004213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}