{"id":"W4410513110","doi":"10.3899/jrheum.2025-0390.pv065","title":"BLOCKING IL-7 SIGNALING PREVENTS THE DEVELOPMENT OF LUPUS-LIKE AUTOIMMUNITY IN MICE BY RESTRICTING T CELL EXPANSION, ACTIVATION, AND COMMUNICATION WITH STROMAL CELLS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Autoimmunity; Medicine; Systemic lupus erythematosus; Stromal cell; Immunology; Blocking (statistics); Lupus erythematosus; Cell biology; Cancer research; Pathology; Immune system; Antibody; Biology; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770261,0.0006998712,0.0004161068,0.0005488825,0.0002713853,0.000441574,0.0003759262,0.000485749,0.00485999],"category_scores_gemma":[0.00008704651,0.0001911918,0.0003371093,0.000207781,0.0003911289,0.0002616315,0.0002151735,0.001358715,0.001881316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003968747,"about_ca_system_score_gemma":0.0003005728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004407134,"about_ca_topic_score_gemma":0.0009934902,"domain_scores_codex":[0.999483,0.00007161363,0.00005135607,0.000112759,0.0001372464,0.0001439981],"domain_scores_gemma":[0.9997423,0.00001591391,0.00009637844,0.0000242023,0.00001651768,0.0001045577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002057575,0.00006530481,0.0001241822,0.00003624196,0.000003773197,0.00003084801,0.00000879367,0.00003321381,0.9985384,0.0000866152,0.00009686501,0.0007699225],"study_design_scores_gemma":[0.00005147979,0.000693278,0.003645632,0.00001961798,0.00002469938,0.0002404204,0.00003485148,0.0005333893,0.9920002,0.00007114307,0.002679201,0.00000611633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819733,0.002362353,0.005216993,0.0004498397,0.0001277858,0.0001023048,0.003410424,0.0006698445,0.005687044],"genre_scores_gemma":[0.9834673,0.001093845,0.004800451,0.0002035637,0.00005300248,0.0001145631,0.001867663,0.0002062429,0.008193375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00485999,"threshold_uncertainty_score":0.01625824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007637296954193627,"score_gpt":0.211436977414325,"score_spread":0.2037996804601313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}