{"id":"W4410513115","doi":"10.3899/jrheum.2025-0390.pv073","title":"SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS IN HEALTHY VOLUNTEERS OF VENT-03, A NOVEL CGAS INHIBITOR FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Pharmacodynamics; Pharmacokinetics; Tolerability; Pharmacology; Systemic lupus erythematosus; Lupus erythematosus; Adverse effect; Internal medicine; Immunology; Antibody","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006235113,0.0003538145,0.0006362576,0.0001452587,0.0001972219,0.000320882,0.0001840924,0.0005275501,0.001475076],"category_scores_gemma":[0.0007155443,0.0002049565,0.0002941495,0.0001111379,0.000315841,0.0002538684,0.0001288756,0.000643793,0.0004256413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001436585,"about_ca_system_score_gemma":0.000214631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002787513,"about_ca_topic_score_gemma":0.0003778464,"domain_scores_codex":[0.9997521,0.000110283,0.00001597529,0.00005410504,0.00003457067,0.00003291949],"domain_scores_gemma":[0.999681,0.00005726402,0.00009175808,0.00002599473,0.00003183625,0.0001121761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.427113,0.01779825,0.03481972,0.0006081731,0.0006480925,0.000640611,0.0004559104,0.001118711,0.3484146,0.0001636389,0.002670502,0.1655487],"study_design_scores_gemma":[0.02361647,0.791694,0.1400042,0.00005954651,0.0007124477,0.001594815,0.0002293806,0.002489751,0.03455366,0.0001753181,0.004798261,0.00007219586],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971638,0.001347063,0.000445792,0.00005652272,0.00002537308,0.000181882,0.0002345478,0.00004663674,0.0004984273],"genre_scores_gemma":[0.9978095,0.0004533002,0.000463455,0.0001122421,0.00005252832,0.000143144,0.0002186588,0.000009900334,0.000737238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475076,"threshold_uncertainty_score":0.004934609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02346766327907757,"score_gpt":0.3364925130656964,"score_spread":0.3130248497866189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}