{"id":"W4410513119","doi":"10.3899/jrheum.2025-0390.o010","title":"RANDOMIZED, PLACEBO-CONTROLLED PHASE II STUDY OF ENPATORAN, A SMALL MOLECULE TOLL-LIKE RECEPTOR 7/8 INHIBITOR, IN CUTANEOUS LUPUS ERYTHEMATOSUS: RESULTS FROM COHORT A","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Mount Sinai Hospital","funders":"","keywords":"Medicine; Placebo; Cutaneous Lupus Erythematosus; Cohort; Lupus erythematosus; Internal medicine; Toll; Randomized controlled trial; Dermatology; Immunology; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003779767,0.002170057,0.003872209,0.0004978447,0.0009424413,0.001599113,0.00104588,0.002394267,0.008668148],"category_scores_gemma":[0.003146018,0.0009645674,0.002822335,0.0004319991,0.001437544,0.001664637,0.000590628,0.003839129,0.00162579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000837706,"about_ca_system_score_gemma":0.002593762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128405,"about_ca_topic_score_gemma":0.002631246,"domain_scores_codex":[0.9989045,0.0005267509,0.00007641224,0.0002254486,0.00008730231,0.0001796381],"domain_scores_gemma":[0.9978181,0.0004214383,0.0004710548,0.0002606915,0.0002636334,0.0007651553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9740656,0.01388085,0.0008469941,0.0002462146,0.001088579,0.00002820306,0.00004057284,0.0001313294,0.002237818,0.0000674808,0.0009738923,0.006392428],"study_design_scores_gemma":[0.925015,0.07141594,0.0019082,0.00002155043,0.0005154241,0.00002138606,0.00001772585,0.0001220693,0.0002224623,0.0001207599,0.0006075373,0.00001195205],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680443,0.004628454,0.00165089,0.0009789411,0.001097054,0.01653699,0.003924347,0.0001844706,0.002954639],"genre_scores_gemma":[0.9499158,0.0042414,0.004399314,0.003686429,0.001398214,0.02445403,0.004418155,0.00006855225,0.007418131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008668148,"threshold_uncertainty_score":0.02899784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01422237989774538,"score_gpt":0.2843071206691273,"score_spread":0.2700847407713819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}