{"id":"W4410513121","doi":"10.3899/jrheum.2025-0390.pv261","title":"DEVELOPMENT OF A QUANTITATIVE SYSTEMS PHARMACOLOGY (QSP) MODEL FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) FOR THERAPEUTIC EVALUATION IN A VIRTUAL POPULATION","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Lupus erythematosus; Population; Pharmacology; Intensive care medicine; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00109118,0.0007256126,0.0008276677,0.0004658789,0.0003616761,0.001056166,0.0009746983,0.001354144,0.003190886],"category_scores_gemma":[0.002901583,0.000401052,0.001252986,0.0003172788,0.0006613598,0.0006003881,0.001026375,0.001487935,0.0004173357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00104461,"about_ca_system_score_gemma":0.001756681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008874576,"about_ca_topic_score_gemma":0.004653275,"domain_scores_codex":[0.9996141,0.0001526503,0.00001861691,0.00007573489,0.00008979626,0.00004918843],"domain_scores_gemma":[0.9982604,0.001248601,0.0001349728,0.00005239034,0.0002413741,0.00006230377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00001897914,0.00001897149,0.0003635539,0.00003223513,0.00001264259,0.00004729459,0.00002473652,0.990019,0.0009924922,0.006229351,0.0002402851,0.002000396],"study_design_scores_gemma":[0.000006210395,0.00001744523,0.00005686934,0.00000343571,0.000005174174,0.000007696275,0.000004753273,0.9978417,0.0001515891,0.00150748,0.0003947567,0.000002814577],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.04819357,0.0003604881,0.935743,0.001026585,0.00009642557,0.000231946,0.0009917645,0.0003978563,0.01295838],"genre_scores_gemma":[0.8419154,0.0007105994,0.1402376,0.0005053481,0.00009017783,0.001214581,0.0009139166,0.0001316119,0.01428074],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.008874576,"threshold_uncertainty_score":0.01764584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07427643434565404,"score_gpt":0.3959215977228413,"score_spread":0.3216451633771873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}