{"id":"W4410513127","doi":"10.3899/jrheum.2025-0390.pv063","title":"NOVEL 3-BASE OLIGONUCLEOTIDE THERAPEUTIC SOF-SKN™ ANTAGONISES TLR7/8 IN AUTOIMMUNE SKIN DISEASE","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; TLR7; Autoimmune disease; Oligonucleotide; Disease; Dermatology; Immunology; Internal medicine; Gene; Innate immune system; Genetics; Immune system; Toll-like receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001270479,0.0003288046,0.0002850716,0.0001557508,0.00007518896,0.0001145612,0.0001710821,0.0003347005,0.001262972],"category_scores_gemma":[0.00006656756,0.00008746245,0.0002477934,0.00006213968,0.0001184796,0.0001290375,0.0001381381,0.0003792994,0.0003287312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001045708,"about_ca_system_score_gemma":0.0001325445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001007378,"about_ca_topic_score_gemma":0.0001693681,"domain_scores_codex":[0.9999421,0.00001010624,0.000005436659,0.000009710276,0.00001425808,0.00001838146],"domain_scores_gemma":[0.9999729,0.000003868842,0.000009243558,0.000001742563,0.00000347661,0.000008747169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004227998,0.0001565247,0.0001415079,0.00009650494,0.00001087294,0.0001283167,0.00001330012,0.0003384155,0.9853757,0.0001536707,0.0001605944,0.01300179],"study_design_scores_gemma":[0.0003721325,0.01090004,0.002069128,0.00002957684,0.00006989594,0.001484012,0.00002320021,0.002320498,0.973056,0.0001260408,0.009535394,0.0000140589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855642,0.003586821,0.006781975,0.000186219,0.0001459124,0.0001663933,0.0001774541,0.0001360679,0.003254886],"genre_scores_gemma":[0.9895538,0.001927428,0.005619993,0.0001521619,0.00004126092,0.0001112228,0.0002434382,0.00001278846,0.002337956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262972,"threshold_uncertainty_score":0.004225016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086023994224612,"score_gpt":0.2536346731887016,"score_spread":0.2427744332464555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}