{"id":"W4410513193","doi":"10.3899/jrheum.2025-0390.o021","title":"INTERFERON-INDUCED PROTEIN EXPRESSION IN THE PERIPHERAL BLOOD IMMUNE POPULATIONS OF SLE PATIENTS AT A SINGLE-CELL LEVEL: ASSOCIATION WITH CELLULAR ACTIVATION, TRAFFICKING MOLECULES, AND DISEASE ACTIVITY","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto Western Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Immunology; Immune system; Interferon; Immune dysregulation; Cell; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001819354,0.0002149551,0.0003247499,0.0007149741,0.0002191324,0.000443115,0.0000870334,0.0002928793,0.001595164],"category_scores_gemma":[0.0004595729,0.0001121982,0.0001447675,0.0003979621,0.0001587392,0.0002010607,0.0002088206,0.0002598168,0.0002890087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000121335,"about_ca_system_score_gemma":0.00004520916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002551978,"about_ca_topic_score_gemma":0.000257467,"domain_scores_codex":[0.9998467,0.00002757243,0.00002214784,0.00005018787,0.00002503357,0.00002829062],"domain_scores_gemma":[0.9996758,0.00008967445,0.0001088029,0.00002101025,0.000038076,0.00006662858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002164841,0.0001011117,0.7811791,0.00006260299,0.00006293396,0.0005518132,0.0003191448,0.0001479163,0.206858,0.00004057096,0.0001565128,0.008355437],"study_design_scores_gemma":[0.00001509861,0.0003973521,0.9916247,0.000004678274,0.00002583912,0.00108766,0.0001345871,0.0002210952,0.006263644,0.00002678013,0.0001940449,0.000004500679],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999386,0.0001391587,0.00009477419,0.000006552747,0.000001516414,0.000004636545,0.0001470448,0.000004199705,0.0002161205],"genre_scores_gemma":[0.9992968,0.00006050945,0.0002013839,0.00001626676,0.000006358513,0.00001103342,0.0002336041,0.000002579721,0.000171436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001595164,"threshold_uncertainty_score":0.005336344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132541078066378,"score_gpt":0.2368815140581082,"score_spread":0.2155561032774444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}