{"id":"W4410513218","doi":"10.3899/jrheum.2025-0390.pv182","title":"MODULAR GENE EXPRESSION CHANGES IN THE SLEEK PHASE 2 STUDY OF UPADACITINIB AND ABBV-599 IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Lupus erythematosus; Connective tissue disease; Internal medicine; Dermatology; Immunology; Autoimmune disease; Antibody","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009844651,0.0002763275,0.0009390331,0.0002608529,0.0001810882,0.0006198738,0.0001825756,0.0003584019,0.002942101],"category_scores_gemma":[0.0007057845,0.0001922308,0.0006151807,0.0002773955,0.0002672379,0.0001632851,0.0001374547,0.0006586833,0.000347153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004314631,"about_ca_system_score_gemma":0.000418346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003640496,"about_ca_topic_score_gemma":0.0006406747,"domain_scores_codex":[0.9995314,0.0001661363,0.0000219731,0.0001281781,0.00008130348,0.00007117664],"domain_scores_gemma":[0.9996629,0.0001242429,0.00007502938,0.00002940755,0.00004151324,0.00006688556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.479371,0.01071892,0.1288313,0.0005886261,0.002208571,0.0003101082,0.0002884876,0.00465354,0.2607645,0.0004196003,0.00295264,0.1088926],"study_design_scores_gemma":[0.05519918,0.1818719,0.6759214,0.0000589137,0.003548057,0.000931584,0.000400985,0.01331575,0.06143259,0.0008698788,0.006342627,0.0001072195],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977295,0.0005204979,0.0002487305,0.00004923096,0.00002256382,0.00009429408,0.0009169857,0.00001332153,0.0004048987],"genre_scores_gemma":[0.9959573,0.0001725191,0.0006654285,0.0001629759,0.00002358753,0.0002306118,0.001817347,0.000008534359,0.0009615298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002942101,"threshold_uncertainty_score":0.009842336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01348848844913749,"score_gpt":0.2782020182651114,"score_spread":0.264713529815974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}