{"id":"W4410518381","doi":"10.1093/jac/dkaf157","title":"Repurposing antimalarials: pyrimethamine exhibits superior <i>in vitro</i> activity to metronidazole against <i>Gardnerella</i> while sparing <i>Lactobacillus</i>","year":2025,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Foreign, Commonwealth and Development Office; National Institute for Health and Care Research; Medical Research Council Canada; Department of Health and Social Care; Wellcome Trust","keywords":"Metronidazole; Repurposing; Microbiology; Pyrimethamine; Sulfadiazine; In vitro; Pharmacology; Lactobacillus; Medicine; Dalbavancin; Chemistry; Antibiotics; Biology; Vancomycin; Staphylococcus aureus; Immunology; Bacteria; Malaria; Plasmodium falciparum","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460516,0.0003835301,0.0003034376,0.0001794936,0.0001018256,0.0002423354,0.0002153412,0.0003023138,0.001292227],"category_scores_gemma":[0.0002346635,0.0001010975,0.0003088547,0.0001565423,0.0001149881,0.0001851752,0.0001717953,0.0002746853,0.0002763678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001601688,"about_ca_system_score_gemma":0.0001980493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000657948,"about_ca_topic_score_gemma":0.0009135616,"domain_scores_codex":[0.9998463,0.00003145243,0.00002117299,0.00003116496,0.00004615768,0.00002364504],"domain_scores_gemma":[0.9998895,0.00001552137,0.00004103874,0.00001424113,0.00002414836,0.00001553787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001042885,0.00003793934,0.0002482059,0.0001104314,0.000007315109,0.00003204415,0.000006456995,0.0000423615,0.9960431,0.00001372676,0.00004316921,0.003310969],"study_design_scores_gemma":[0.00002187709,0.001568399,0.003953028,0.00001472765,0.00003142925,0.0004277508,0.00001334689,0.0003193018,0.9915849,0.00001017184,0.002051129,0.000003883596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878185,0.007496962,0.001793727,0.0001626889,0.00004389479,0.00006859941,0.0005000826,0.00007824413,0.002037334],"genre_scores_gemma":[0.9921649,0.00280879,0.002818055,0.00006984892,0.00001552094,0.00002608516,0.0006319135,0.000009305492,0.001455614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292227,"threshold_uncertainty_score":0.004322946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01551872684473484,"score_gpt":0.2838793584232485,"score_spread":0.2683606315785137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}