{"id":"W4410518951","doi":"10.3390/reactions6020034","title":"Design and Synthesis of E7820/Tasisulam Hybrids as Potential DCAF15 Binders","year":2025,"lang":"en","type":"article","venue":"Reactions","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Servier","keywords":"Hybrid; Biology; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009183033,0.00006483099,0.00007295236,0.00006862776,0.00007199392,0.00001123552,0.00005164042,0.00007131122,0.000016374],"category_scores_gemma":[0.0001430781,0.00006454286,0.00004419422,0.00008539185,0.00006104908,0.00000380513,0.00003022637,0.00004057553,0.000005030658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008106117,"about_ca_system_score_gemma":0.00007778262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004514596,"about_ca_topic_score_gemma":0.000001973054,"domain_scores_codex":[0.9995517,0.00004527994,0.0001243987,0.0001449135,0.00005394113,0.0000797826],"domain_scores_gemma":[0.9997028,0.00001892617,0.0000443627,0.0001588225,0.00004357758,0.00003152121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003952647,0.00007046408,0.00009227563,0.00001676228,0.00007861546,8.214685e-7,0.000005588485,0.00009462537,0.9849162,0.0005960153,0.00421174,0.009877442],"study_design_scores_gemma":[0.0001780984,0.00004785777,0.0005335766,0.00001942003,0.00003560521,0.0000111491,0.00008060804,0.0001185872,0.9764897,0.0002654777,0.02215212,0.00006781267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8830122,0.001064581,0.09859113,0.001783501,0.00048669,0.0005254219,0.00002048878,0.00004488945,0.0144711],"genre_scores_gemma":[0.9966967,0.0004225316,0.001261817,0.00007627496,0.00003556364,0.00002459998,0.0000135956,0.000005842496,0.001463042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1136845,"threshold_uncertainty_score":0.2631981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007067005845366752,"score_gpt":0.2469274437401603,"score_spread":0.2398604378947935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}