{"id":"W4410521054","doi":"10.1038/s41467-025-59898-6","title":"Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida auris","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"State Key Laboratory of Pathogen and Biosecurity; Stockholms Universitet; Huashan Hospital; Nanchang University; Recruitment Program of Global Experts; Science for Life Laboratory; Government of Jiangsu Province; Chinese Academy of Sciences; Fudan University; Institute of Microbiology, Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Candida auris; Biology; Drug resistance; Antifungal drug; Acetylation; Echinocandin; Virulence; Histone; Fungal protein; Microbiology; Epigenetics; Candida albicans; Mutant; Genetics; Gene; Antifungal; Fluconazole","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009562341,0.0001837916,0.0001338779,0.0001729907,0.0000925536,0.0002656788,0.0001372396,0.0001641679,0.001339507],"category_scores_gemma":[0.00007099943,0.00005299765,0.0001328965,0.00008944498,0.0001525914,0.00008879198,0.0001930169,0.0002586616,0.0001655252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003220408,"about_ca_system_score_gemma":0.000187798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007208119,"about_ca_topic_score_gemma":0.001577939,"domain_scores_codex":[0.9999411,0.000005999382,0.00000345638,0.00001204919,0.00002255654,0.00001480855],"domain_scores_gemma":[0.9999673,0.00000369988,0.00001154924,0.000003932013,0.000005742002,0.000007697958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001321801,0.00002882431,0.0007187646,0.0001011715,0.00001124588,0.0000673884,0.000011787,0.0003211669,0.9833151,0.0003057322,0.0002711154,0.01471548],"study_design_scores_gemma":[0.00003818401,0.0005701679,0.01186078,0.00003480608,0.00005144937,0.0005719984,0.00005713869,0.002404712,0.9639017,0.0002388047,0.02026123,0.000008956947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663657,0.01789623,0.007000859,0.0006931737,0.0001522799,0.0000928542,0.0006620974,0.0003175745,0.00681929],"genre_scores_gemma":[0.99255,0.002881334,0.002068414,0.0001364575,0.00001867393,0.00001945309,0.0002087701,0.0000095283,0.002107325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339507,"threshold_uncertainty_score":0.004481077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01266493842903781,"score_gpt":0.3341957509928124,"score_spread":0.3215308125637746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}