{"id":"W4410522521","doi":"10.1002/alz.70242","title":"Relationships between neuropsychiatric symptoms, subtypes of astrocyte activities, and brain pathologies in Alzheimer's disease and Parkinson's disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Avid Radiopharmaceuticals; Allergan; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Genentech; Weston Family Foundation; Voyager Therapeutics; Aligning Science Across Parkinson’s; Neurocrine Biosciences; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Cerevel Therapeutics; Jazz Pharmaceuticals; IXICO; Amathus Therapeutics; Takeda Pharmaceutical Company; AbbVie; Biohaven Pharmaceuticals; Celgene; Pfizer; Biogen; University of Southern California; Roche; Merck; GlaxoSmithKline; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Michael J. Fox Foundation for Parkinson's Research; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Janssen Biotech; Verily Life Sciences; Teva Pharmaceutical Industries; Meso Scale Diagnostics; Sanofi; Northern California Institute for Research and Education; UCB; Fujirebio US; Alzheimer's Association","keywords":"Glial fibrillary acidic protein; Disease; Pathological; Amyloid beta; Astrocyte; Alpha-synuclein; Alzheimer's disease; Tau protein; Parkinson's disease; Pathology; Neuroscience; Neurology; Medicine; Psychology; Central nervous system; Immunohistochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003578581,0.0002945396,0.0002816643,0.000888548,0.0003802581,0.0004703473,0.0001575952,0.000207703,0.000823722],"category_scores_gemma":[0.0008347252,0.00009503626,0.0002745913,0.0006765166,0.0002091601,0.0002364668,0.0004221293,0.0002216929,0.000134098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002943711,"about_ca_system_score_gemma":0.0002891697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003272667,"about_ca_topic_score_gemma":0.006247256,"domain_scores_codex":[0.9997956,0.00003577744,0.00004097814,0.0000540798,0.00004810609,0.00002537835],"domain_scores_gemma":[0.999418,0.0000620197,0.0002896772,0.00002097848,0.0001171718,0.00009224329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001606915,0.00001909616,0.995223,0.00003066132,0.0000892751,0.00007931022,0.00008630523,0.00005116611,0.0007096818,0.00001372434,0.00006182892,0.003475367],"study_design_scores_gemma":[0.000002061032,0.00003119311,0.999097,0.000009138682,0.00003121987,0.0003178216,0.0001287546,0.0001204994,0.0001082602,0.00004691644,0.0001051036,0.000002214266],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997995,0.00102969,0.0001412457,0.00004375628,0.000005696507,0.000009794159,0.0002185258,0.000004690468,0.0005515097],"genre_scores_gemma":[0.9991699,0.0002434081,0.0002525089,0.000009883973,0.000007494588,0.000006127793,0.0002024196,0.000001215673,0.0001070499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003272667,"threshold_uncertainty_score":0.006507218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02319284535007514,"score_gpt":0.2708005055968196,"score_spread":0.2476076602467444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}