{"id":"W4410525430","doi":"10.1161/circulationaha.124.073233","title":"Efficacy and Safety of Inclisiran in Adolescents With Genetically Confirmed Homozygous Familial Hypercholesterolemia: Results From the Double-Blind, Placebo-Controlled Part of the ORION-13 Randomized Trial","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Novartis Pharma","keywords":"Familial hypercholesterolemia; Medicine; PCSK9; Placebo; Internal medicine; Statin; Hyperlipidemia; Compound heterozygosity; Randomized controlled trial; Alirocumab; Gastroenterology; Lipoprotein; LDL receptor; Endocrinology; Cholesterol; Diabetes mellitus; Mutation; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001571565,0.001091848,0.002628468,0.0002568259,0.0002795804,0.0008265415,0.0006917646,0.001648919,0.004104226],"category_scores_gemma":[0.001505957,0.0004404746,0.001825549,0.0002504889,0.0007334868,0.0005949084,0.0003539569,0.002326791,0.0004564527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005826087,"about_ca_system_score_gemma":0.0007757299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006542101,"about_ca_topic_score_gemma":0.001571893,"domain_scores_codex":[0.9993524,0.0004019018,0.00004895245,0.00008761158,0.00004498878,0.00006412368],"domain_scores_gemma":[0.999175,0.0002133543,0.000267324,0.00005938264,0.0000588148,0.000226099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9820854,0.002576736,0.001669368,0.0005765365,0.001175103,0.00004137879,0.00004018778,0.0001321949,0.001299541,0.00005982471,0.0003845168,0.009959244],"study_design_scores_gemma":[0.9578738,0.03449089,0.005588234,0.00007690347,0.001022702,0.00004667613,0.00002682978,0.0002162859,0.0002512908,0.0000537527,0.0003427135,0.00001009229],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907734,0.006201691,0.0001859467,0.0003645096,0.0001846581,0.000749338,0.0005110354,0.00004325075,0.0009862025],"genre_scores_gemma":[0.9914911,0.003283509,0.0007284103,0.0006060473,0.0002395522,0.001365628,0.0008623988,0.00001384251,0.001409498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004104226,"threshold_uncertainty_score":0.01372999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0194826513401305,"score_gpt":0.2695670847781227,"score_spread":0.2500844334379922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}