{"id":"W4410537865","doi":"10.1038/s41380-025-03023-y","title":"Cholinergic system in schizophrenia: A systematic review and meta-analysis","year":2025,"lang":"en","type":"review","venue":"Molecular Psychiatry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Ottawa Hospital; Royal Ottawa Mental Health Centre; Université du Québec en Outaouais; University of Ottawa","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Meta-analysis; Schizophrenia (object-oriented programming); Cholinergic; Psychology; Neuroscience; Cholinergic system; Psychosis; MEDLINE; Medicine; Psychiatry; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01016159,0.002614703,0.01620605,0.008741504,0.0007954229,0.003001641,0.002121924,0.002078696,0.00481167],"category_scores_gemma":[0.02348349,0.001295051,0.02759488,0.009067501,0.0006333834,0.001597969,0.001698346,0.001404782,0.0003777731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002630963,"about_ca_system_score_gemma":0.005555904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00761719,"about_ca_topic_score_gemma":0.02042936,"domain_scores_codex":[0.9927296,0.002972835,0.002439775,0.0007292669,0.0008386138,0.0002900017],"domain_scores_gemma":[0.9856876,0.009733954,0.00248615,0.0004028659,0.001467528,0.000222023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0007901277,0.0000208453,0.003357419,0.7064261,0.2735958,0.000173397,0.0001043983,0.0003383941,0.0002342761,0.0001378424,0.0008199101,0.01400155],"study_design_scores_gemma":[0.000371919,0.000204888,0.005767053,0.0938575,0.8956378,0.0002170348,0.00008677308,0.000145835,0.0001244964,0.0002275499,0.003324105,0.00003516122],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002031531,0.9965537,0.0002913696,0.0001619715,0.00008214947,0.000210797,0.0005043031,0.00001354938,0.0001507639],"genre_scores_gemma":[0.06444518,0.9315416,0.001544229,0.0005424658,0.0001733563,0.0008580833,0.0006833483,0.00001634145,0.0001954341],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01620605,"threshold_uncertainty_score":0.05374026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01676191116481779,"score_gpt":0.2985537192853731,"score_spread":0.2817918081205553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}