{"id":"W4410542119","doi":"10.1016/j.xcrm.2025.102088","title":"Targeting STING antagonism in HSV-1: A peptide-based strategy to restore antiviral immunity and suppress viral pathogenesis","year":2025,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Beijing Academy of Agricultural and Forestry Sciences","keywords":"Sting; Pathogenesis; Herpes simplex virus; Virology; Stimulator of interferon genes; Immunity; Interferon; HSL and HSV; Virus; Viral replication; Immunology; Biology; Antagonism; Medicine; Innate immune system; Immune system; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001077042,0.0002552162,0.0005104797,0.0003970433,0.0002053708,0.00001603836,0.0001431344,0.0002073816,0.0001240548],"category_scores_gemma":[0.0007275057,0.0002144652,0.0000501825,0.0002463872,0.0002770554,0.00006579045,0.0001396941,0.0004240186,0.000009480616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006319456,"about_ca_system_score_gemma":0.0001824587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009017026,"about_ca_topic_score_gemma":0.00002950177,"domain_scores_codex":[0.9979086,0.0003985246,0.000746478,0.0004357906,0.00005647794,0.0004541176],"domain_scores_gemma":[0.998989,0.0002879376,0.0001970072,0.0004007111,0.00009122481,0.00003411731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004642472,0.00009203056,0.01889848,0.00009325593,0.00002437426,0.0004540967,0.0006033968,0.00002442026,0.9736202,0.000028199,0.002085928,0.003611334],"study_design_scores_gemma":[0.002563098,0.001078719,0.1014511,0.0008368611,0.00008335748,0.000162512,0.003748045,0.00006638544,0.8745722,0.0000586817,0.01496711,0.0004119426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877672,0.00581017,0.0002150913,0.0003741553,0.0009577519,0.0003506594,0.000006210839,0.00005951136,0.004459294],"genre_scores_gemma":[0.9929545,0.00007194449,0.00005987829,0.0003839238,0.00003405998,0.00002321922,0.0001119371,0.00001831769,0.006342238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09904801,"threshold_uncertainty_score":0.8745638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163414967993729,"score_gpt":0.2653493819674629,"score_spread":0.2537152322875256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}