{"id":"W4410551268","doi":"10.1089/crispr.2025.0051","title":"Summitting CRISPR for Human Heritable Genome Editing","year":2025,"lang":"en","type":"article","venue":"The CRISPR Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"CRISPR; Genome editing; Biology; Genome; Computational biology; Genetics; Human genome; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006929651,0.0001441066,0.0001378701,0.00005114292,0.0006460501,0.0001135707,0.0003376585,0.00008432927,0.00002525008],"category_scores_gemma":[0.0001489092,0.0001137925,0.0001523275,0.00008421806,0.0000424346,0.000004506952,0.0001079849,0.0002229673,0.00000263836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000202288,"about_ca_system_score_gemma":0.00004974719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000072111,"about_ca_topic_score_gemma":0.00001315589,"domain_scores_codex":[0.9990242,0.00003882737,0.0002848627,0.0001837602,0.00009573063,0.0003726778],"domain_scores_gemma":[0.9994406,0.00002852396,0.00008180421,0.000256511,0.0001278367,0.00006475985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002830749,0.00002616596,0.0006832024,0.00005152506,0.0001276928,0.000002790814,0.0001336906,0.00143499,0.9778222,0.0004895212,0.0165251,0.002674782],"study_design_scores_gemma":[0.001340521,0.0002433506,0.002459754,0.00008989289,0.0001352905,0.0001246233,0.001834935,0.0004769982,0.5655034,0.002418509,0.4250053,0.0003674453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4510133,0.008185041,0.5320851,0.002035015,0.001456672,0.0003888181,0.00001593922,0.00003371896,0.004786463],"genre_scores_gemma":[0.9928679,0.0001189089,0.001854303,0.0004383782,0.002052794,0.00002109448,0.00001559359,0.00002668006,0.002604289],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5418547,"threshold_uncertainty_score":0.4968961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00982039644892763,"score_gpt":0.3416341780640494,"score_spread":0.3318137816151218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}