{"id":"W4410551268","doi":"10.1089/crispr.2025.0051","title":"Summitting CRISPR for Human Heritable Genome Editing","year":2025,"lang":"en","type":"article","venue":"The CRISPR Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"CRISPR; Genome editing; Biology; Genome; Computational biology; Genetics; Human genome; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01999665,0.0004167558,0.0003202793,0.0006445245,0.003595362,0.008726246,0.0008425252,0.005858874,0.006732817],"category_scores_gemma":[0.01865511,0.0001866113,0.0005245531,0.00037834,0.007012124,0.003801198,0.006348958,0.008450396,0.001416672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002757336,"about_ca_system_score_gemma":0.003756611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007918702,"about_ca_topic_score_gemma":0.002148266,"domain_scores_codex":[0.991091,0.003595444,0.0003282009,0.0008017067,0.003262671,0.0009210602],"domain_scores_gemma":[0.9798189,0.01465327,0.0008418158,0.001017264,0.001755203,0.001913522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001670957,0.00007207186,0.001218713,0.0005650151,0.00005276834,0.001373557,0.01084422,0.0006081757,0.01015287,0.5816299,0.2802637,0.1130521],"study_design_scores_gemma":[0.00001576891,0.0001021588,0.0007782212,0.0004448937,0.00002916108,0.0004060352,0.003974272,0.0002726093,0.007070229,0.09815721,0.8887012,0.00004818834],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03094687,0.03633576,0.0285257,0.6346271,0.05607921,0.0001445197,0.0002221293,0.0004186623,0.2127001],"genre_scores_gemma":[0.5437389,0.0298954,0.02029184,0.2220271,0.02370273,0.0003014717,0.000311213,0.0005152409,0.1592161],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01999665,"threshold_uncertainty_score":0.1057537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00982039644892763,"score_gpt":0.3416341780640494,"score_spread":0.3318137816151218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}