{"id":"W4410551311","doi":"10.21203/rs.3.rs-6597595/v1","title":"GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute on Aging; Instituto de Salud Carlos III; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; Canadian Institutes of Health Research; National Institutes of Health; Fleni; IXICO; Servier; H. Lundbeck A/S; Deutsches Zentrum für Neurodegenerative Erkrankungen; Eisai; Korea Health Industry Development Institute; Northern California Institute for Research and Education; Japan Agency for Medical Research and Development; Novartis Pharmaceuticals Corporation; Ministry of Science and ICT, South Korea; Genentech; National Alzheimer's Coordinating Center; Biogen; BioClinica; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; University of Southern California; Hope Center for Neurological Disorders; Alzheimer's Association; Bristol-Myers Squibb; U.S. Department of Veterans Affairs; Foundation for the National Institutes of Health","keywords":"Genome-wide association study; Autophagy; Gene; Lipid metabolism; Biology; Disease; Genetics; Alzheimer's disease; Brain size; Bioinformatics; Medicine; Single-nucleotide polymorphism; Pathology; Biochemistry; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002166238,0.001501168,0.001760815,0.001457541,0.0007816807,0.001719873,0.0007767865,0.001375384,0.003731591],"category_scores_gemma":[0.004226694,0.000903938,0.005531189,0.002440528,0.0003971351,0.0005048294,0.0008324751,0.001065207,0.000349196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003111781,"about_ca_system_score_gemma":0.0004846927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007505237,"about_ca_topic_score_gemma":0.01022489,"domain_scores_codex":[0.9981837,0.0005121421,0.0001642843,0.0007530844,0.0001820133,0.0002046484],"domain_scores_gemma":[0.998041,0.0009482667,0.0002969418,0.0004485835,0.0001248702,0.0001403248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.009431829,0.00009062143,0.8349793,0.0006067739,0.1168006,0.00150446,0.0003417174,0.001490687,0.01306376,0.0007430213,0.003143036,0.01780422],"study_design_scores_gemma":[0.0006651041,0.000396746,0.9057593,0.0001046168,0.08218268,0.001122012,0.0002557864,0.002433178,0.001900906,0.002127053,0.00299963,0.0000530094],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641526,0.02275121,0.005241934,0.0009165062,0.0003264001,0.00002160372,0.004761126,0.0002679609,0.001560592],"genre_scores_gemma":[0.9964591,0.0009705229,0.0008698748,0.0001247679,0.00007905705,0.00001423622,0.0007955286,0.00004434893,0.0006425445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007505237,"threshold_uncertainty_score":0.0149231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1060063554497313,"score_gpt":0.4016506501594454,"score_spread":0.2956442947097141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}