{"id":"W4410552606","doi":"10.1101/2025.05.20.654665","title":"Molecular Control of Non-Muscle Myosin II-A Aggregation and Intracellular Dynamics by motor- or tail-specific <i>MYH9</i> Mutations","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Ministerio de Ciencia e Innovación","keywords":"Myosin; Intracellular; Molecular motor; Dynamics (music); Cell biology; Chemistry; Control (management); Biophysics; Genetics; Biology; Computer science; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009143713,0.0002416511,0.0001054324,0.000105625,0.00009868524,0.0001560929,0.0001433018,0.0002580224,0.001679919],"category_scores_gemma":[0.00008519355,0.00007649793,0.0001653739,0.00006326297,0.0001710544,0.00006914926,0.0001342159,0.000237169,0.0004988303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001811797,"about_ca_system_score_gemma":0.00006006563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004222828,"about_ca_topic_score_gemma":0.0006650222,"domain_scores_codex":[0.9999036,0.00002259349,0.00001338342,0.00002711814,0.00001863801,0.00001471983],"domain_scores_gemma":[0.9999313,0.00001181657,0.00003196759,0.00000787749,0.000003495018,0.00001356295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007156551,0.00001631869,0.0003630506,0.00001480266,0.00000416172,0.0001440539,0.000005723261,0.00004072868,0.998498,0.00007009168,0.00005214338,0.0007194441],"study_design_scores_gemma":[0.000058362,0.0002844816,0.02772612,0.000009503352,0.00002348408,0.002331719,0.00002317554,0.001785306,0.9635787,0.0000861824,0.004086287,0.000006717793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955314,0.0004966025,0.001601959,0.00006789981,0.00003051915,0.00002838763,0.0006565385,0.00008065333,0.001506112],"genre_scores_gemma":[0.997031,0.0002028221,0.001235213,0.00002858574,0.000008440377,0.00002460708,0.0003161479,0.00002857892,0.001124626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679919,"threshold_uncertainty_score":0.005619943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006544795273682957,"score_gpt":0.2134357520649368,"score_spread":0.2068909567912538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}