{"id":"W4410552667","doi":"10.1186/s13062-025-00634-x","title":"Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans","year":2025,"lang":"en","type":"article","venue":"Biology Direct","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Biology; Longevity; Hydroxytyrosol; Caenorhabditis elegans; Stage (stratigraphy); Physiology; Genetics; Gene; Antioxidant; Polyphenol; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002016768,0.0001327,0.000193218,0.00009088485,0.00004132374,0.00001037618,0.0001248484,0.0002026535,0.000007112985],"category_scores_gemma":[0.00007343659,0.0001350594,0.00004346597,0.00008961553,0.0001716111,0.000002927178,0.00008427531,0.00008071401,0.000001171889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008257933,"about_ca_system_score_gemma":0.00007585036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001583289,"about_ca_topic_score_gemma":0.0003980778,"domain_scores_codex":[0.999103,0.00009199419,0.0002351553,0.0003314779,0.00003550047,0.0002028504],"domain_scores_gemma":[0.9995946,0.0000200065,0.00007025951,0.0002422197,0.0000351995,0.00003767443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006682421,0.00005543888,0.1926996,0.00004166925,0.00004825633,0.000003551889,0.0002027114,0.00002831903,0.8043743,0.0007361479,0.00009828006,0.00164491],"study_design_scores_gemma":[0.0007722739,0.0005256523,0.1701654,0.00003556279,0.00003488908,0.000007118731,0.00009094267,0.000292848,0.8188287,0.0004478861,0.008522231,0.0002765121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946329,0.001470893,0.001209562,0.0001882679,0.0001375464,0.000123196,0.00002272735,0.00001169532,0.002203235],"genre_scores_gemma":[0.9979095,0.0004342291,0.0004446821,0.0001741387,0.00004351311,0.00001198538,0.00005885653,0.00001019757,0.000912899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02253421,"threshold_uncertainty_score":0.5507562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007376366749634386,"score_gpt":0.2658923985172258,"score_spread":0.2585160317675914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}