{"id":"W4410557387","doi":"10.3389/fped.2025.1601409","title":"Emerging therapeutic strategies for cystinosis","year":2025,"lang":"en","type":"review","venue":"Frontiers in Pediatrics","topic":"Biomedical Research and Pathophysiology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Cystinosis; Cysteamine; Medicine; Bench to bedside; Intensive care medicine; Bioinformatics; Pediatrics; Internal medicine; Cystine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004081766,0.000319075,0.001759695,0.00104757,0.00005510856,0.00002446911,0.0002780457,0.0006503982,0.00002255423],"category_scores_gemma":[0.0006396421,0.0002434371,0.0005154456,0.001236299,0.0001031828,0.00003785924,0.00007266892,0.0007439965,0.000008043546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000181347,"about_ca_system_score_gemma":0.002734536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006899127,"about_ca_topic_score_gemma":0.000001146084,"domain_scores_codex":[0.997989,0.0001337806,0.0005584137,0.0004509054,0.0002797575,0.0005881173],"domain_scores_gemma":[0.9986252,0.0006425417,0.0001448266,0.000325501,0.00008425715,0.0001776908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004002447,0.00005628549,0.00006531079,0.06927376,0.00007264617,0.00002637036,0.00001640793,1.276296e-7,8.028868e-8,0.0001265163,0.05370229,0.8766202],"study_design_scores_gemma":[0.00047078,0.0002055485,0.000009990295,0.002919694,0.0009905633,0.000004343811,0.00008802454,0.00003942071,5.065803e-8,0.00248968,0.9925876,0.0001943088],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[5.519687e-7,0.9753569,0.02034735,0.000104501,0.001718073,0.001437439,0.0001224733,0.00003872951,0.0008739706],"genre_scores_gemma":[0.000001736354,0.9895767,0.007467909,0.0001491195,0.000920329,0.000414392,0.0003608504,0.00003464549,0.001074324],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9388853,"threshold_uncertainty_score":0.9927077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04435969072161591,"score_gpt":0.3910529324730875,"score_spread":0.3466932417514716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}