{"id":"W4410560663","doi":"10.1530/etj-25-0057","title":"NOVEL INSIGHTS IN ADVANCED THYROID CARCINOMA: FROM MECHANISMS TO TREATMENTS: Molecular insights into the origin, biology, and treatment of anaplastic thyroid carcinoma","year":2025,"lang":"en","type":"review","venue":"European Thyroid Journal","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Western University","funders":"Canadian Institutes of Health Research; Physicians' Services Incorporated Foundation","keywords":"Medicine; MAPK/ERK pathway; Anaplastic thyroid cancer; Cancer research; Thyroid carcinoma; Thyroid cancer; Papillary thyroid cancer; Malignancy; Genome instability; Targeted therapy; Cancer; Bioinformatics; Thyroid; Oncology; Internal medicine; Biology; Signal transduction; Genetics; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004269638,0.0005223211,0.0009977977,0.001740336,0.0002376974,0.0008569554,0.0006165592,0.0008598214,0.002518215],"category_scores_gemma":[0.0006147414,0.0001795989,0.000435654,0.001392706,0.0003566042,0.001046633,0.0005495271,0.002009012,0.001401482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006518436,"about_ca_system_score_gemma":0.0008359668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000992651,"about_ca_topic_score_gemma":0.002026274,"domain_scores_codex":[0.9998645,0.00002242509,0.00001770715,0.00002170498,0.00005870487,0.00001485118],"domain_scores_gemma":[0.9997782,0.0001011986,0.0000250779,0.000005976199,0.00006779064,0.00002179288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006937228,0.00006581302,0.0001468402,0.01347489,0.00006997721,0.0002991584,0.00006770751,0.0004843577,0.002343951,0.003807929,0.03133933,0.9478306],"study_design_scores_gemma":[0.00001554399,0.00009588287,0.0006909376,0.003201843,0.00007279547,0.001563472,0.00005209045,0.0001183732,0.00039861,0.002268868,0.9915057,0.00001585456],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001111467,0.9986368,0.0001095976,0.0003455401,0.0001782379,0.000002695095,0.00001356508,0.000006491609,0.0005959053],"genre_scores_gemma":[0.000644981,0.9984716,0.0001272645,0.000218017,0.0001512312,0.000003432126,0.00002097387,0.000001320478,0.000361139],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002518215,"threshold_uncertainty_score":0.008424222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02348740213138881,"score_gpt":0.3023547114058812,"score_spread":0.2788673092744923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}