{"id":"W4410560663","doi":"10.1530/etj-25-0057","title":"NOVEL INSIGHTS IN ADVANCED THYROID CARCINOMA: FROM MECHANISMS TO TREATMENTS: Molecular insights into the origin, biology, and treatment of anaplastic thyroid carcinoma","year":2025,"lang":"en","type":"review","venue":"European Thyroid Journal","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Western University","funders":"Canadian Institutes of Health Research; Physicians' Services Incorporated Foundation","keywords":"Medicine; MAPK/ERK pathway; Anaplastic thyroid cancer; Cancer research; Thyroid carcinoma; Thyroid cancer; Papillary thyroid cancer; Malignancy; Genome instability; Targeted therapy; Cancer; Bioinformatics; Thyroid; Oncology; Internal medicine; Biology; Signal transduction; Genetics; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0002599748,0.001524056,0.003605105,0.001190737,0.0003353784,0.0001194125,0.0006538557,0.0002918439,0.00002595195],"category_scores_gemma":[0.000132762,0.0008869106,0.0009783059,0.001035924,0.000208609,0.0001413195,0.0003231965,0.0007660399,0.000054318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001784144,"about_ca_system_score_gemma":0.0009746334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006166118,"about_ca_topic_score_gemma":0.0003512123,"domain_scores_codex":[0.9943773,0.0009928755,0.001930864,0.001401332,0.0005201591,0.0007774271],"domain_scores_gemma":[0.9961632,0.00063045,0.001010387,0.001309772,0.0002250041,0.0006611181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001579332,0.005822299,0.001711066,0.002205923,0.006890651,0.008296655,0.008826698,0.00006815378,0.01019942,0.003938674,0.0006495939,0.9498115],"study_design_scores_gemma":[0.04573983,0.04319808,0.01857849,0.02930758,0.02126276,0.001753693,0.001509942,0.00003465446,0.002615476,0.001900909,0.8307312,0.003367359],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09779454,0.8972199,0.0004340732,0.0002189872,0.0006590624,0.002494581,0.0001708074,0.00004392977,0.0009641091],"genre_scores_gemma":[0.08879278,0.9076921,0.001871701,0.0002348346,0.000410174,0.0002644987,0.0002825381,0.0001842217,0.0002671618],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9464442,"threshold_uncertainty_score":0.9997508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02348740213138881,"score_gpt":0.3023547114058812,"score_spread":0.2788673092744923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}