{"id":"W4410579331","doi":"10.3899/jrheum.2025-0390.pv277","title":"EFAVALEUKIN ALFA IN PATIENTS WITH ACTIVE SYSTEMIC LUPUS ERYTHEMATOSUS: RESULTS OF A BAYESIAN ADAPTIVE, PHASE 2B, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED DOSE-RANGING STUDY","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Dose-ranging study; Placebo; Double blind; Internal medicine; Randomized controlled trial; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004604545,0.001827333,0.003651543,0.0004980592,0.0004642863,0.001054811,0.0006929018,0.002097492,0.003937885],"category_scores_gemma":[0.002969389,0.0007419562,0.002069201,0.0004084249,0.001231458,0.001186455,0.0003838875,0.00235036,0.0007219572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005797095,"about_ca_system_score_gemma":0.001137499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003875419,"about_ca_topic_score_gemma":0.0006928024,"domain_scores_codex":[0.9979742,0.001287268,0.0001325269,0.0002766063,0.0001591314,0.0001702059],"domain_scores_gemma":[0.9982756,0.0005896876,0.000361341,0.0001721608,0.0001704442,0.0004307776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.946698,0.02179625,0.0010588,0.000418941,0.001305059,0.00003827815,0.00005999035,0.0005952787,0.004551985,0.00008197997,0.0006134933,0.02278179],"study_design_scores_gemma":[0.8849912,0.11064,0.002421702,0.00002177543,0.0005213366,0.00002666755,0.00001361401,0.0004997494,0.0002783129,0.0001045142,0.0004614636,0.00001960922],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863527,0.004159629,0.001892235,0.0006855925,0.0002958977,0.004179316,0.0008297667,0.0001545802,0.00145029],"genre_scores_gemma":[0.9848162,0.002238805,0.003671397,0.001555135,0.0004283304,0.004676424,0.0009781373,0.00003813711,0.001597588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004604545,"threshold_uncertainty_score":0.02435148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01738150508856098,"score_gpt":0.3056540564642303,"score_spread":0.2882725513756694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}