{"id":"W4410579358","doi":"10.3899/jrheum.2025-0390.pv264","title":"DESIGN OF A PHASE 2A, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF MK-6194, AN INTERLEUKIN-2 MUTEIN, IN ADULT PARTICIPANTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Placebo; Double blind; Randomized controlled trial; Internal medicine; Multicenter study; Lupus erythematosus; Multicenter trial; Systemic disease; Immunopathology; Immunology; Pathology; Antibody; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004348245,0.003041099,0.003996921,0.0006391381,0.001074533,0.001727177,0.001324432,0.004021849,0.01023978],"category_scores_gemma":[0.002664358,0.001391683,0.001615583,0.0004270379,0.002189745,0.002157136,0.0007682636,0.003671814,0.001922017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007946551,"about_ca_system_score_gemma":0.002352053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004947921,"about_ca_topic_score_gemma":0.001191933,"domain_scores_codex":[0.9981605,0.0008820974,0.0001081725,0.0004369296,0.0001035858,0.0003085913],"domain_scores_gemma":[0.9984645,0.0003032197,0.000298998,0.0001356442,0.0001450417,0.0006525531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9681128,0.01930589,0.0004783371,0.0003920749,0.0003457033,0.00004397266,0.00005520812,0.000185666,0.0034092,0.0001286895,0.0006340941,0.00690854],"study_design_scores_gemma":[0.9048894,0.09316751,0.0006027658,0.00001704568,0.0001574056,0.00001545285,0.00001381529,0.0001558945,0.0002370729,0.0001386635,0.0005935764,0.00001139309],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9011895,0.004937468,0.003426022,0.001969034,0.00223278,0.07878152,0.002333177,0.0004168289,0.004713643],"genre_scores_gemma":[0.8838292,0.002241612,0.008554108,0.005097645,0.001463015,0.0904456,0.001294205,0.0000667475,0.007007868],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01023978,"threshold_uncertainty_score":0.0342555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04086019717664813,"score_gpt":0.3481384103167826,"score_spread":0.3072782131401344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}