{"id":"W4410579459","doi":"10.3899/jrheum.2025-0390.pv262","title":"IANALUMAB’S DUAL MODE OF ACTION: TARGETING B CELLS THROUGH ENHANCED B CELL DEPLETION AND BLOCKADE OF B CELL-ACTIVATING FACTOR RECEPTOR SIGNALING","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Receptor; Blockade; Signal transduction; Cell biology; B cell; Mode of action; Cell; Dual (grammatical number); Cancer research; Immunology; Internal medicine; Antibody; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001647717,0.0004171718,0.0003292462,0.000248619,0.0001159913,0.0003171164,0.0002911687,0.0003230011,0.002011508],"category_scores_gemma":[0.00005902015,0.0001016413,0.0001990779,0.0001438305,0.0001469061,0.0001815486,0.0001308394,0.0008049787,0.0007359977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002157319,"about_ca_system_score_gemma":0.0001286343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001740054,"about_ca_topic_score_gemma":0.0002801805,"domain_scores_codex":[0.9999038,0.00002210285,0.000006059793,0.00001513206,0.00002151586,0.00003133308],"domain_scores_gemma":[0.9999777,0.00000233899,0.000005441033,0.000002526983,0.000002847549,0.000009124626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006208968,0.0002727841,0.000204539,0.0001171823,0.00001416848,0.0001029055,0.00001467308,0.0001520956,0.981979,0.0002845444,0.000601071,0.01563614],"study_design_scores_gemma":[0.0002650793,0.004241521,0.003156587,0.00001213042,0.00005483047,0.001736887,0.00001425665,0.0008420611,0.9697582,0.000108398,0.01979695,0.00001316092],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9581109,0.01625787,0.006880923,0.000711688,0.0002061093,0.0001775704,0.0005445016,0.0002668957,0.01684356],"genre_scores_gemma":[0.9802999,0.00504388,0.005423269,0.0002099585,0.000105482,0.0001379559,0.0005169476,0.00002453586,0.008237867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002011508,"threshold_uncertainty_score":0.006729186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02457174578623603,"score_gpt":0.3194643638910647,"score_spread":0.2948926181048286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}