{"id":"W4410580146","doi":"10.1007/s00204-025-04085-1","title":"Temporal analyses of germ cell mutations using the MutaMouse model support the recommended design in OECD test guideline 488","year":2025,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Health Canada; Canada Research Chairs","keywords":"Confidence interval; Andrology; Toxicology; Animal science; Germ cell; Chemistry; Biology; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003718436,0.0001204705,0.0002065407,0.000116218,0.0000616368,0.000004848976,0.0003948087,0.00008328111,0.00001554094],"category_scores_gemma":[0.0002319136,0.00008207266,0.0001173222,0.00009792131,0.0002236452,0.00000300838,0.0002139076,0.0001024196,5.1986e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008097019,"about_ca_system_score_gemma":0.0003175528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006039929,"about_ca_topic_score_gemma":0.0001508046,"domain_scores_codex":[0.9987609,0.0002769994,0.000490313,0.000219237,0.00006269872,0.0001898726],"domain_scores_gemma":[0.9989455,0.0003264105,0.0002269008,0.0004403412,0.00003787604,0.00002298565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006885009,0.0001904883,0.0009058535,0.00001296811,0.0000467629,0.00000192469,0.0001856471,0.0373273,0.9599189,0.0002111947,0.00055889,0.0005712186],"study_design_scores_gemma":[0.0004330565,0.0002721355,0.0001866551,0.00000600661,0.0000586512,0.000005513323,0.0002647548,0.1123137,0.8811482,0.005026597,0.000211153,0.00007356569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8089834,0.0001933659,0.1857913,0.001580991,0.00008606776,0.000550509,0.00005757991,0.00001039168,0.002746352],"genre_scores_gemma":[0.9506806,0.00002719655,0.04832031,0.0004733894,0.00001493768,0.00002255138,0.00003952851,0.00001114725,0.0004103843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1416971,"threshold_uncertainty_score":0.3346826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05007720217186993,"score_gpt":0.3523249951827324,"score_spread":0.3022477930108624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}