{"id":"W4410580793","doi":"10.26508/lsa.202403191","title":"Inhibition of xanthine oxidoreductase with febuxostat, but not allopurinol, prevents inflammasome assembly and IL-1β release","year":2025,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Research (Canada); BC Children's Hospital; University of British Columbia","funders":"University of British Columbia; Michael Smith Health Research BC; BC Children's Hospital; Canadian Institutes of Health Research; Faculty of Medicine, University of British Columbia; Banting Research Foundation; Juvenile Diabetes Research Foundation Canada","keywords":"Inflammasome; Febuxostat; Allopurinol; Uric acid; Gout; Macrophage; Xanthine oxidase; Xanthine; Pharmacology; Chemistry; Biochemistry; Biology; In vitro; Medicine; Enzyme; Hyperuricemia; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001854526,0.0002685274,0.0004003616,0.0001974196,0.0001286457,0.0002594186,0.0001168422,0.0003046865,0.001438693],"category_scores_gemma":[0.0001583479,0.00009879136,0.0003169659,0.0001262352,0.0002250918,0.000191849,0.0001212957,0.0005781775,0.0002217775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001375665,"about_ca_system_score_gemma":0.0001476466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001981657,"about_ca_topic_score_gemma":0.0003350111,"domain_scores_codex":[0.9998366,0.00004296873,0.00001757979,0.00003104292,0.00003236072,0.00003939815],"domain_scores_gemma":[0.9999303,0.00001311423,0.00002516528,0.000008609629,0.000005844788,0.00001697097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001531909,0.0001463827,0.0002985988,0.000129354,0.00002244633,0.00009920498,0.00002036159,0.00004872158,0.9929265,0.00008308784,0.0001538212,0.004539495],"study_design_scores_gemma":[0.0001344547,0.001827103,0.004938794,0.00001217635,0.00003339188,0.0004780709,0.00003192855,0.000326036,0.9885124,0.00005232678,0.003648556,0.000004879805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984884,0.008644793,0.003434727,0.000358722,0.0001821929,0.00007000248,0.000349345,0.0001216276,0.001954623],"genre_scores_gemma":[0.993229,0.002264692,0.002349789,0.0001706946,0.00004216611,0.00005778312,0.0003351923,0.00001347631,0.001537059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001438693,"threshold_uncertainty_score":0.004812956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235902199098765,"score_gpt":0.2684364843910826,"score_spread":0.256077462400095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}