{"id":"W4410589402","doi":"10.1097/pas.0000000000002412","title":"Dominant Negative PTEN Alterations in Endometrial Carcinoma Are Associated With Retained Immunohistochemical PTEN Expression","year":2025,"lang":"en","type":"article","venue":"The American Journal of Surgical Pathology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"PTEN; Immunohistochemistry; Carcinoma; Cancer research; Biology; Carcinosarcoma; Pathology; Medicine; Genetics; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004543595,0.0001426996,0.000175814,0.0007363439,0.0001718777,0.0002334112,0.0001584625,0.0001740131,0.0006748099],"category_scores_gemma":[0.001327453,0.0001355253,0.0001541248,0.0004594802,0.0002797009,0.0001461685,0.0002949102,0.0001155565,0.0001325361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000147274,"about_ca_system_score_gemma":0.0001527682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000981545,"about_ca_topic_score_gemma":0.001779212,"domain_scores_codex":[0.9997213,0.00004154755,0.0000462193,0.00004708596,0.00007857384,0.00006524527],"domain_scores_gemma":[0.9994475,0.0001103478,0.0002151013,0.00006951821,0.00007310062,0.0000844164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000532409,0.00001703695,0.9524636,0.00004536763,0.00003952988,0.004719332,0.000177511,0.00008674594,0.03449677,0.00006216931,0.00007047917,0.007288965],"study_design_scores_gemma":[0.000009288576,0.0001770618,0.9743667,0.0000110595,0.00005903185,0.01958089,0.0002297059,0.0003389851,0.004516435,0.00008400557,0.0006209753,0.000005862115],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990681,0.0004375601,0.0001105109,0.000007520442,0.000001721922,0.000003875758,0.00003735267,0.000002633747,0.0003306829],"genre_scores_gemma":[0.999676,0.0001207919,0.00009985438,0.000004800659,0.000001742431,0.000001668482,0.00003025142,7.508168e-7,0.0000641655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000981545,"threshold_uncertainty_score":0.002402961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009207645326984964,"score_gpt":0.2686063746059232,"score_spread":0.2593987292789383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}