{"id":"W4410595562","doi":"10.1158/2643-3230.bcd-25-0099","title":"B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with <i>MYC</i> and <i>BCL2</i> Rearrangements","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Optech (Canada)","funders":"H2020 Marie Skłodowska-Curie Actions; Fondazione Beretta; Fondazione Cariplo; American Society of Hematology; Fondazione AIRC per la ricerca sul cancro ETS","keywords":"Gene silencing; B cell; Cancer research; Biology; Cell; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006219,0.0001348864,0.0001060674,0.0001568443,0.0000717479,0.0003473822,0.000130532,0.0001493407,0.001208395],"category_scores_gemma":[0.00006639905,0.0001034379,0.0001227042,0.0001119424,0.0001042517,0.0001592292,0.0001469097,0.0004435473,0.0004652486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349534,"about_ca_system_score_gemma":0.00008997306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005937101,"about_ca_topic_score_gemma":0.0008773968,"domain_scores_codex":[0.999897,0.000009546101,0.000007413391,0.00002230503,0.0000262724,0.00003757793],"domain_scores_gemma":[0.9999284,0.00001168528,0.00002042889,0.00001089541,0.000006895347,0.00002171836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006607679,0.00001787093,0.0005493743,0.000005991273,0.000002310675,0.0000246769,0.000007123259,0.00003617299,0.998343,0.00007860715,0.00002474777,0.0008441258],"study_design_scores_gemma":[0.00001221947,0.0002172541,0.01920114,0.000002825198,0.00001762372,0.0004244176,0.0000413714,0.001348685,0.9771254,0.00005113224,0.001554414,0.000003533926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971554,0.0003738118,0.0008452056,0.00002264741,0.000004456491,0.000008739059,0.0002188306,0.00006547866,0.001305383],"genre_scores_gemma":[0.9978988,0.000176243,0.0003356815,0.00001948442,0.000002810559,0.000008629263,0.0003857319,0.00002190473,0.001150684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001208395,"threshold_uncertainty_score":0.004042506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01386809793508148,"score_gpt":0.2705367684569447,"score_spread":0.2566686705218633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}