{"id":"W4410595562","doi":"10.1158/2643-3230.bcd-25-0099","title":"B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with <i>MYC</i> and <i>BCL2</i> Rearrangements","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Optech (Canada)","funders":"H2020 Marie Skłodowska-Curie Actions; Fondazione Beretta; Fondazione Cariplo; American Society of Hematology; Fondazione AIRC per la ricerca sul cancro ETS","keywords":"Gene silencing; B cell; Cancer research; Biology; Cell; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003508456,0.0002414794,0.000455354,0.0001202627,0.0001312481,0.00008307653,0.0001715198,0.00008798247,0.0001612288],"category_scores_gemma":[0.00002014077,0.0001574212,0.00006348325,0.0004016536,0.0003475352,0.0001987917,0.0001443023,0.0002284976,0.000001825785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009753291,"about_ca_system_score_gemma":0.0004579517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00228419,"about_ca_topic_score_gemma":0.0002851885,"domain_scores_codex":[0.9982505,0.00009296238,0.000300228,0.0004528747,0.0005315245,0.0003719245],"domain_scores_gemma":[0.9989873,0.0001927194,0.0001296475,0.0004914496,0.00009626776,0.0001026161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000999358,0.0004051135,0.0791975,0.001159767,0.0003749469,0.00002000272,0.0006228108,0.000007568217,0.9076926,0.0002288611,0.006892122,0.002399342],"study_design_scores_gemma":[0.011914,0.0006313627,0.007419755,0.00112375,0.0008306054,0.00003136257,0.001534501,0.0000084954,0.9633613,0.0002340227,0.01261493,0.0002958892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735877,0.01833027,0.00002207574,0.001190501,0.0001388425,0.0007900051,0.00007414904,0.00002627673,0.005840183],"genre_scores_gemma":[0.9560406,0.01156365,0.0002329401,0.0007211455,0.000120392,0.0001240345,0.00001041157,0.0000358763,0.03115091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07177775,"threshold_uncertainty_score":0.6419449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01386809793508148,"score_gpt":0.2705367684569447,"score_spread":0.2566686705218633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}