{"id":"W4410595775","doi":"10.1016/j.semcancer.2025.05.011","title":"The central role of Pin1 in age-related cancer signaling pathways","year":2025,"lang":"en","type":"review","venue":"Seminars in Cancer Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Ontario Institute for Cancer Research","keywords":"PIN1; Prolyl isomerase; Phosphorylation; Isomerase; Signal transduction; Peptidylprolyl isomerase; Regulator; Expansive; Biology; Cancer; Cancer research; Cell biology; Chemistry; Biochemistry; Enzyme; Genetics; Gene; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004496641,0.0004666326,0.001125094,0.000163082,0.00006135382,0.00001191823,0.000868091,0.000933772,0.00004028494],"category_scores_gemma":[0.000256324,0.0003602463,0.0003900644,0.0005225215,0.0003915937,0.000002011503,0.0003281641,0.0004907129,0.000001486051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002447343,"about_ca_system_score_gemma":0.001653144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005669629,"about_ca_topic_score_gemma":0.0008414352,"domain_scores_codex":[0.9969484,0.0005037031,0.0009871013,0.0007571152,0.0001047851,0.0006988843],"domain_scores_gemma":[0.9985314,0.0002484329,0.0004690597,0.0006144412,0.00006016485,0.00007652399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000774224,0.00008832746,0.001629838,0.002820069,0.0002412794,0.00002297303,0.0001143058,0.0001864238,0.01157075,0.0003121414,0.0004245782,0.9825119],"study_design_scores_gemma":[0.0005780586,0.0001495971,0.00004144426,0.02653019,0.0002401231,0.000005910517,0.0001025932,0.00001044766,0.009503302,0.00131089,0.960892,0.0006355066],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005107692,0.9923902,0.000003193373,0.00002087987,0.0007186569,0.0007445756,0.0005229861,0.00001097571,0.0004808677],"genre_scores_gemma":[0.008502045,0.9897422,0.00003575637,0.00005095219,0.0001888985,0.0008005236,0.000410097,0.00004678104,0.0002227565],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9818764,"threshold_uncertainty_score":0.999885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02101057256726889,"score_gpt":0.3376802243330037,"score_spread":0.3166696517657348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}