{"id":"W4410598207","doi":"10.1148/ryct.240204","title":"Preclinical Evaluation of a Nanobody-based SPECT Radiotracer <sup>99m</sup>Tc-AFN with Clinical Potential for Noninvasive Monitoring of Fibroblast Activation after Myocardial Infarction","year":2025,"lang":"en","type":"article","venue":"Radiology Cardiothoracic Imaging","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aurora College","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China; Beijing Hospital Authority","keywords":"Myocardial infarction; Medicine; Fibroblast activation protein, alpha; Technetium-99m; Technetium; Nuclear medicine; Cardiology; Internal medicine; Scintigraphy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005940509,0.0005705745,0.0005499059,0.0002201237,0.000167274,0.0003139638,0.0005987841,0.0006903306,0.001105386],"category_scores_gemma":[0.0002743526,0.0002342495,0.0002741751,0.0001832586,0.0003883387,0.0002970066,0.0001324959,0.0008372315,0.0002950302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002909703,"about_ca_system_score_gemma":0.0005059502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009962579,"about_ca_topic_score_gemma":0.001472839,"domain_scores_codex":[0.9998692,0.00003895193,0.000005699611,0.00002298324,0.00003624388,0.00002689654],"domain_scores_gemma":[0.9998468,0.00003616718,0.00002958866,0.00001376687,0.00003453556,0.00003913261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001630201,0.0009976287,0.0002133217,0.0001161977,0.00002915407,0.00008530261,0.00003385275,0.0003892739,0.9893579,0.0001165475,0.0002174967,0.006813186],"study_design_scores_gemma":[0.0004989995,0.02754613,0.001942787,0.00001770968,0.0001694631,0.0003986747,0.00004895277,0.003042857,0.9619707,0.00008673482,0.004260922,0.00001602767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671909,0.005809715,0.02224779,0.0004116914,0.0001541261,0.0006659981,0.0005024929,0.000230539,0.002786703],"genre_scores_gemma":[0.9790487,0.003307737,0.01344551,0.0002531938,0.00004829694,0.0006916483,0.0008114782,0.0000449844,0.002348365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001105386,"threshold_uncertainty_score":0.003697932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02544241053860961,"score_gpt":0.3752982591837804,"score_spread":0.3498558486451708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}