{"id":"W4410603940","doi":"10.1038/s43018-025-00979-2","title":"Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer","year":2025,"lang":"en","type":"article","venue":"Nature Cancer","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"Canadian Cancer Society Research Institute","keywords":"Lung cancer; Melanoma; Antigen; Cancer research; Cancer; Biology; Computational biology; Genetics; Oncology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001030764,0.0002499192,0.0003691321,0.0001824652,0.0001402317,0.00002858057,0.000266834,0.0005111603,0.0006205277],"category_scores_gemma":[0.00001713703,0.0002169044,0.00006360903,0.0002248634,0.0001544787,0.00007579906,0.00008284763,0.0008610208,0.00001207775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001725675,"about_ca_system_score_gemma":0.0006215926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005074786,"about_ca_topic_score_gemma":0.003834715,"domain_scores_codex":[0.998688,0.0001728051,0.0002754135,0.0004240549,0.00002636978,0.0004133799],"domain_scores_gemma":[0.9994522,0.0001369779,0.0001147194,0.0002138293,0.0000687807,0.00001347517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009543137,0.00004659449,0.0663028,0.00005273543,0.0004046028,0.00000941759,0.0009744604,0.00003526972,0.9263417,0.00003846071,0.001126384,0.003713282],"study_design_scores_gemma":[0.002659648,0.00005077746,0.369818,0.000335777,0.0001105206,0.000003090841,0.0002720759,0.00002461779,0.6099598,0.00009611335,0.0163626,0.0003069697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7511488,0.2462411,0.00002432258,0.0002462344,0.001525345,0.0003101833,0.0001620344,0.00002833062,0.0003136456],"genre_scores_gemma":[0.9848905,0.009974621,0.00005079904,0.0009034195,0.00003362197,0.0001086,0.00007058852,0.00001953692,0.00394837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3163819,"threshold_uncertainty_score":0.8845103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005052376149050756,"score_gpt":0.2516496343244254,"score_spread":0.2465972581753747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}